Liu X - Search Results

1

Use of Intravenous Infusion Study Design to Simultaneously Determine Brain Penetration and Systemic Pharmacokinetic Parameters in Rats.

Noh K, Pietrasiewicz A, Liu X, Wei C. Noh K, et al. Among authors: liu x. Drug Metab Dispos. 2021 Feb;49(2):142-151. doi: 10.1124/dmd.120.000242. Epub 2020 Dec 1. Drug Metab Dispos. 2021. PMID: 33262223

2

Optimizing transcardial perfusion of small molecules and biologics for brain penetration and biodistribution studies in rodents.

Noh K, Liu X, Wei C. Noh K, et al. Among authors: liu x. Biopharm Drug Dispos. 2023 Feb;44(1):71-83. doi: 10.1002/bdd.2317. Epub 2022 May 16. Biopharm Drug Dispos. 2023. PMID: 35508078

3

Use of cassette dosing to enhance the throughput of rat brain microdialysis studies.

Deshmukh G, Sun K, Liederer BM, Ding X, Liu X. Deshmukh G, et al. Among authors: liu x. Drug Metab Dispos. 2015 Jul;43(7):1123-8. doi: 10.1124/dmd.115.064204. Epub 2015 May 5. Drug Metab Dispos. 2015. PMID: 25943358

4

Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats.

Durk MR, Deshmukh G, Valle N, Ding X, Liederer BM, Liu X. Durk MR, et al. Among authors: liu x. Drug Metab Dispos. 2018 Jul;46(7):964-969. doi: 10.1124/dmd.118.080697. Epub 2018 Apr 26. Drug Metab Dispos. 2018. PMID: 29700231

5

Evaluation of the utility of brain slice methods to study brain penetration.

Becker S, Liu X. Becker S, et al. Among authors: liu x. Drug Metab Dispos. 2006 May;34(5):855-61. doi: 10.1124/dmd.105.007914. Epub 2006 Feb 24. Drug Metab Dispos. 2006. PMID: 16501003

6

Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration.

Liu X, Smith BJ, Chen C, Callegari E, Becker SL, Chen X, Cianfrogna J, Doran AC, Doran SD, Gibbs JP, Hosea N, Liu J, Nelson FR, Szewc MA, Van Deusen J. Liu X, et al. Among authors: liu j. Drug Metab Dispos. 2006 Sep;34(9):1443-7. doi: 10.1124/dmd.105.008201. Epub 2006 Jun 7. Drug Metab Dispos. 2006. PMID: 16760229

7

Unbound drug concentration in brain homogenate and cerebral spinal fluid at steady state as a surrogate for unbound concentration in brain interstitial fluid.

Liu X, Van Natta K, Yeo H, Vilenski O, Weller PE, Worboys PD, Monshouwer M. Liu X, et al. Drug Metab Dispos. 2009 Apr;37(4):787-93. doi: 10.1124/dmd.108.024125. Epub 2008 Dec 30. Drug Metab Dispos. 2009. PMID: 19116265

8

Use of the cassette-dosing approach to assess brain penetration in drug discovery.

Liu X, Ding X, Deshmukh G, Liederer BM, Hop CE. Liu X, et al. Drug Metab Dispos. 2012 May;40(5):963-9. doi: 10.1124/dmd.111.044420. Epub 2012 Feb 10. Drug Metab Dispos. 2012. PMID: 22328585

9

Development of a computational approach to predict blood-brain barrier permeability.

Liu X, Tu M, Kelly RS, Chen C, Smith BJ. Liu X, et al. Drug Metab Dispos. 2004 Jan;32(1):132-9. doi: 10.1124/dmd.32.1.132. Drug Metab Dispos. 2004. PMID: 14709630

10

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.

Zhang D, Hop CECA, Patilea-Vrana G, Gampa G, Seneviratne HK, Unadkat JD, Kenny JR, Nagapudi K, Di L, Zhou L, Zak M, Wright MR, Bumpus NN, Zang R, Liu X, Lai Y, Khojasteh SC. Zhang D, et al. Among authors: liu x. Drug Metab Dispos. 2019 Oct;47(10):1122-1135. doi: 10.1124/dmd.119.086744. Epub 2019 Jul 2. Drug Metab Dispos. 2019. PMID: 31266753 Free PMC article. Review.

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