Tal-Singer R - Search Results

1

CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin.

Keir HR, Richardson H, Fillmore C, Shoemark A, Lazaar AL, Miller BE, Tal-Singer R, Chalmers JD, Mohan D. Keir HR, et al. ERJ Open Res. 2020 Nov 10;6(4):00583-2020. doi: 10.1183/23120541.00583-2020. eCollection 2020 Oct. ERJ Open Res. 2020. PMID: 33263062 Free PMC article.

2

Evaluation of exhaled breath condensate pH as a biomarker for COPD.

MacNee W, Rennard SI, Hunt JF, Edwards LD, Miller BE, Locantore NW, Tal-Singer R. MacNee W, et al. Respir Med. 2011 Jul;105(7):1037-45. doi: 10.1016/j.rmed.2011.02.009. Epub 2011 Mar 4. Respir Med. 2011. PMID: 21377342 Free article.

3

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans.

Lazaar AL, Sweeney LE, MacDonald AJ, Alexis NE, Chen C, Tal-Singer R. Lazaar AL, et al. Br J Clin Pharmacol. 2011 Aug;72(2):282-93. doi: 10.1111/j.1365-2125.2011.03968.x. Br J Clin Pharmacol. 2011. PMID: 21426372 Free PMC article. Clinical Trial.

4

COPD association and repeatability of blood biomarkers in the ECLIPSE cohort.

Dickens JA, Miller BE, Edwards LD, Silverman EK, Lomas DA, Tal-Singer R; Evaluation of COPD Longitudinally to Identify Surrogate Endpoints (ECLIPSE) study investigators. Dickens JA, et al. Respir Res. 2011 Nov 4;12(1):146. doi: 10.1186/1465-9921-12-146. Respir Res. 2011. PMID: 22054035 Free PMC article. Clinical Trial.

5

Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis.

Moss RB, Mistry SJ, Konstan MW, Pilewski JM, Kerem E, Tal-Singer R, Lazaar AL; CF2110399 Investigators. Moss RB, et al. J Cyst Fibros. 2013 May;12(3):241-8. doi: 10.1016/j.jcf.2012.08.016. Epub 2012 Sep 17. J Cyst Fibros. 2013. PMID: 22995323 Free article. Clinical Trial.

6

Lessons from ECLIPSE: a review of COPD biomarkers.

Faner R, Tal-Singer R, Riley JH, Celli B, Vestbo J, MacNee W, Bakke P, Calverley PM, Coxson H, Crim C, Edwards LD, Locantore N, Lomas DA, Miller BE, Rennard SI, Wouters EF, Yates JC, Silverman EK, Agusti A; ECLIPSE Study Investigators. Faner R, et al. Thorax. 2014 Jul;69(7):666-72. doi: 10.1136/thoraxjnl-2013-204778. Epub 2013 Dec 5. Thorax. 2014. PMID: 24310110 Review.

7

Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality.

Williams MC, Murchison JT, Edwards LD, Agustí A, Bakke P, Calverley PM, Celli B, Coxson HO, Crim C, Lomas DA, Miller BE, Rennard S, Silverman EK, Tal-Singer R, Vestbo J, Wouters E, Yates JC, van Beek EJ, Newby DE, MacNee W; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators. Williams MC, et al. Thorax. 2014 Aug;69(8):718-23. doi: 10.1136/thoraxjnl-2012-203151. Epub 2014 Jan 28. Thorax. 2014. PMID: 24473329

8

The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective CXCR2 antagonist --in healthy adult subjects.

Miller BE, Mistry S, Smart K, Connolly P, Carpenter DC, Cooray H, Bloomer JC, Tal-Singer R, Lazaar AL. Miller BE, et al. BMC Pharmacol Toxicol. 2015 Jun 20;16:18. doi: 10.1186/s40360-015-0017-x. BMC Pharmacol Toxicol. 2015. PMID: 26092545 Free PMC article. Clinical Trial.

9

Low plasma CC16 levels in smokers are associated with a higher risk for chronic bronchitis.

Petersen H, Leng S, Belinsky SA, Miller BE, Tal-Singer R, Owen CA, Celli B, Tesfaigzi Y. Petersen H, et al. Eur Respir J. 2015 Nov;46(5):1501-3. doi: 10.1183/13993003.00682-2015. Epub 2015 Jul 9. Eur Respir J. 2015. PMID: 26160869 Free article. No abstract available.

10

Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor.

Lazaar AL, Yang L, Boardley RL, Goyal NS, Robertson J, Baldwin SJ, Newby DE, Wilkinson IB, Tal-Singer R, Mayer RJ, Cheriyan J. Lazaar AL, et al. Br J Clin Pharmacol. 2016 May;81(5):971-9. doi: 10.1111/bcp.12855. Epub 2016 Jan 17. Br J Clin Pharmacol. 2016. PMID: 26620151 Free PMC article. Clinical Trial.

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