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EGFR inhibition triggers an adaptive response by co-opting antiviral signaling pathways in lung cancer.
Gong K, Guo G, Panchani N, Bender ME, Gerber DE, Minna JD, Fattah F, Gao B, Peyton M, Kernstine K, Mukherjee B, Burma S, Chiang CM, Zhang S, Amod Sathe A, Xing C, Dao KH, Zhao D, Akbay EA, Habib AA. Gong K, et al. Among authors: zhao d. Nat Cancer. 2020 Apr;1(4):394-409. doi: 10.1038/s43018-020-0048-0. Epub 2020 Apr 6. Nat Cancer. 2020. PMID: 33269343 Free PMC article.
RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN.
Park S, Zhao D, Hatanpaa KJ, Mickey BE, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar VM, Chauncey SS, Habib AA. Park S, et al. Among authors: zhao d. Cancer Res. 2009 May 15;69(10):4107-11. doi: 10.1158/0008-5472.CAN-09-0474. Epub 2009 May 12. Cancer Res. 2009. PMID: 19435890 Free PMC article.
Ligand-Independent EGFR Signaling.
Guo G, Gong K, Wohlfeld B, Hatanpaa KJ, Zhao D, Habib AA. Guo G, et al. Among authors: zhao d. Cancer Res. 2015 Sep 1;75(17):3436-41. doi: 10.1158/0008-5472.CAN-15-0989. Epub 2015 Aug 17. Cancer Res. 2015. PMID: 26282175 Free PMC article. Review.
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