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Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis.
Nallar SC, Kalakonda S, Lindner DJ, Lorenz RR, Lamarre E, Weihua X, Kalvakolanu DV. Nallar SC, et al. Among authors: kalakonda s. J Biol Chem. 2013 Mar 15;288(11):7930-7941. doi: 10.1074/jbc.M112.440610. Epub 2013 Feb 5. J Biol Chem. 2013. PMID: 23386605 Free PMC article.
GRIM-19 mutations fail to inhibit v-Src-induced oncogenesis.
Kalakonda S, Nallar SC, Lindner DJ, Sun P, Lorenz RR, Lamarre E, Reddy SP, Kalvakolanu DV. Kalakonda S, et al. Oncogene. 2014 Jun 12;33(24):3195-204. doi: 10.1038/onc.2013.271. Epub 2013 Jul 15. Oncogene. 2014. PMID: 23851499 Free PMC article.
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