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Page 1
N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands.
Wannberg J, Gising J, Lindman J, Salander J, Gutiérrez-de-Terán H, Ablahad H, Hamid S, Grönbladh A, Spizzo I, Gaspari TA, Widdop RE, Hallberg A, Backlund M, Leśniak A, Hallberg M, Larhed M. Wannberg J, et al. Among authors: spizzo i. Bioorg Med Chem. 2021 Jan 1;29:115859. doi: 10.1016/j.bmc.2020.115859. Epub 2020 Nov 7. Bioorg Med Chem. 2021. PMID: 33309749
β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats.
Del Borgo M, Wang Y, Bosnyak S, Khan M, Walters P, Spizzo I, Perlmutter P, Hilliard L, Denton K, Aguilar MI, Widdop RE, Jones ES. Del Borgo M, et al. Among authors: spizzo i. Clin Sci (Lond). 2015 Sep;129(6):505-13. doi: 10.1042/CS20150077. Epub 2015 May 8. Clin Sci (Lond). 2015. PMID: 26186568
Serelaxin and the AT2 Receptor Agonist CGP42112 Evoked a Similar, Nonadditive, Cardiac Antifibrotic Effect in High Salt-Fed Mice That Were Refractory to Candesartan Cilexetil.
Wang Y, Han L, Shen M, Jones ES, Spizzo I, Walton SL, Denton KM, Gaspari TA, Samuel CS, Widdop RE. Wang Y, et al. Among authors: spizzo i. ACS Pharmacol Transl Sci. 2020 Jan 23;3(1):76-87. doi: 10.1021/acsptsci.9b00095. eCollection 2020 Feb 14. ACS Pharmacol Transl Sci. 2020. PMID: 32259090 Free PMC article.
In Aged Females, the Enhanced Pressor Response to Angiotensin II Is Attenuated By Estrogen Replacement via an Angiotensin Type 2 Receptor-Mediated Mechanism.
Barsha G, Mirabito Colafella KM, Walton SL, Gaspari TA, Spizzo I, Pinar AA, Hilliard Krause LM, Widdop RE, Samuel CS, Denton KM. Barsha G, et al. Among authors: spizzo i. Hypertension. 2021 Jul;78(1):128-137. doi: 10.1161/HYPERTENSIONAHA.121.17164. Epub 2021 May 10. Hypertension. 2021. PMID: 33966450
The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy.
Alam F, Gaspari TA, Kemp-Harper BK, Low E, Aw A, Ferens D, Spizzo I, Jefferis AM, Praveen P, Widdop RE, Bathgate RAD, Hossain MA, Samuel CS. Alam F, et al. Among authors: spizzo i. Biomed Pharmacother. 2023 Apr;160:114370. doi: 10.1016/j.biopha.2023.114370. Epub 2023 Feb 6. Biomed Pharmacother. 2023. PMID: 36753958 Free article.
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