Callegari E - Search Results

1

Physiologically-Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co-Administration with the UGT Inhibitor Mefenamic Acid.

Callegari E, Lin J, Tse S, Goosen TC, Sahasrabudhe V. Callegari E, et al. CPT Pharmacometrics Syst Pharmacol. 2021 Feb;10(2):127-136. doi: 10.1002/psp4.12581. Epub 2020 Dec 30. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33314761 Free PMC article. Clinical Trial.

2

Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects.

Miao Z, Nucci G, Amin N, Sharma R, Mascitti V, Tugnait M, Vaz AD, Callegari E, Kalgutkar AS. Miao Z, et al. Among authors: callegari e. Drug Metab Dispos. 2013 Feb;41(2):445-56. doi: 10.1124/dmd.112.049551. Epub 2012 Nov 20. Drug Metab Dispos. 2013. PMID: 23169609 Clinical Trial.

3

Drug metabolites as cytochrome p450 inhibitors: a retrospective analysis and proposed algorithm for evaluation of the pharmacokinetic interaction potential of metabolites in drug discovery and development.

Callegari E, Kalgutkar AS, Leung L, Obach RS, Plowchalk DR, Tse S. Callegari E, et al. Drug Metab Dispos. 2013 Dec;41(12):2047-55. doi: 10.1124/dmd.113.052241. Epub 2013 Jun 21. Drug Metab Dispos. 2013. PMID: 23792812

4

The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine.

Nguyen HQ, Callegari E, Obach RS. Nguyen HQ, et al. Among authors: callegari e. Drug Metab Dispos. 2016 Oct;44(10):1569-78. doi: 10.1124/dmd.116.071639. Epub 2016 Jul 20. Drug Metab Dispos. 2016. PMID: 27440861

5

Prediction of Losartan-Active Carboxylic Acid Metabolite Exposure Following Losartan Administration Using Static and Physiologically Based Pharmacokinetic Models.

Nguyen HQ, Lin J, Kimoto E, Callegari E, Tse S, Obach RS. Nguyen HQ, et al. Among authors: callegari e. J Pharm Sci. 2017 Sep;106(9):2758-2770. doi: 10.1016/j.xphs.2017.03.032. Epub 2017 Apr 12. J Pharm Sci. 2017. PMID: 28412400

6

Role of Hepatic Organic Anion Transporter 2 in the Pharmacokinetics of R- and S-Warfarin: In Vitro Studies and Mechanistic Evaluation.

Bi YA, Lin J, Mathialagan S, Tylaska L, Callegari E, Rodrigues AD, Varma MVS. Bi YA, et al. Among authors: callegari e. Mol Pharm. 2018 Mar 5;15(3):1284-1295. doi: 10.1021/acs.molpharmaceut.7b01108. Epub 2018 Feb 20. Mol Pharm. 2018. PMID: 29433307

7

Novel Application of the Two-Period Microtracer Approach to Determine Absolute Oral Bioavailability and Fraction Absorbed of Ertugliflozin.

Raje S, Callegari E, Sahasrabudhe V, Vaz A, Shi H, Fluhler E, Woolf EJ, Schildknegt K, Matschke K, Alvey C, Zhou S, Papadopoulos D, Fountaine R, Saur D, Terra SG, Stevens L, Gaunt D, Cutler DL. Raje S, et al. Among authors: callegari e. Clin Transl Sci. 2018 Jul;11(4):405-411. doi: 10.1111/cts.12549. Epub 2018 Mar 25. Clin Transl Sci. 2018. PMID: 29575530 Free PMC article. Clinical Trial.

8

Recommendations for the Design of Clinical Drug-Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically-Based Pharmacokinetic Model.

Chen Y, Cabalu TD, Callegari E, Einolf H, Liu L, Parrott N, Peters SA, Schuck E, Sharma P, Tracey H, Upreti VV, Zheng M, Zhu AZX, Hall SD. Chen Y, et al. Among authors: callegari e. CPT Pharmacometrics Syst Pharmacol. 2019 Sep;8(9):685-695. doi: 10.1002/psp4.12449. Epub 2019 Aug 7. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31215774 Free PMC article.

9

Enzalutamide and Apalutamide: In Vitro Chemical Reactivity Studies and Activity in a Mouse Drug Allergy Model.

Ji C, Guha M, Zhu X, Whritenour J, Hemkens M, Tse S, Walker GS, Evans E, Khan NK, Finkelstein MB, Callegari E, Obach RS. Ji C, et al. Among authors: callegari e. Chem Res Toxicol. 2020 Jan 21;33(1):211-222. doi: 10.1021/acs.chemrestox.9b00247. Epub 2019 Oct 9. Chem Res Toxicol. 2020. PMID: 31538772

10

Mini-Review: Comprehensive Drug Disposition Knowledge Generated in the Modern Human Radiolabeled ADME Study.

Spracklin DK, Chen D, Bergman AJ, Callegari E, Obach RS. Spracklin DK, et al. Among authors: callegari e. CPT Pharmacometrics Syst Pharmacol. 2020 Aug;9(8):428-434. doi: 10.1002/psp4.12540. Epub 2020 Jul 31. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32562380 Free PMC article. Review.

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