Lai PK - Search Results

1

Machine Learning Feature Selection for Predicting High Concentration Therapeutic Antibody Aggregation.

Lai PK, Fernando A, Cloutier TK, Kingsbury JS, Gokarn Y, Halloran KT, Calero-Rubio C, Trout BL. Lai PK, et al. J Pharm Sci. 2021 Apr;110(4):1583-1591. doi: 10.1016/j.xphs.2020.12.014. Epub 2020 Dec 18. J Pharm Sci. 2021. PMID: 33346034

2

Machine Learning Applied to Determine the Molecular Descriptors Responsible for the Viscosity Behavior of Concentrated Therapeutic Antibodies.

Lai PK, Fernando A, Cloutier TK, Gokarn Y, Zhang J, Schwenger W, Chari R, Calero-Rubio C, Trout BL. Lai PK, et al. Mol Pharm. 2021 Mar 1;18(3):1167-1175. doi: 10.1021/acs.molpharmaceut.0c01073. Epub 2021 Jan 15. Mol Pharm. 2021. PMID: 33450157

3

Calculation of therapeutic antibody viscosity with coarse-grained models, hydrodynamic calculations and machine learning-based parameters.

Lai PK, Swan JW, Trout BL. Lai PK, et al. MAbs. 2021 Jan-Dec;13(1):1907882. doi: 10.1080/19420862.2021.1907882. MAbs. 2021. PMID: 33834944 Free PMC article.

4

Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions.

Lai PK, Ghag G, Yu Y, Juan V, Fayadat-Dilman L, Trout BL. Lai PK, et al. MAbs. 2021 Jan-Dec;13(1):1991256. doi: 10.1080/19420862.2021.1991256. MAbs. 2021. PMID: 34747330 Free PMC article.

5

Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics.

Lai PK, Gallegos A, Mody N, Sathish HA, Trout BL. Lai PK, et al. MAbs. 2022 Jan-Dec;14(1):2026208. doi: 10.1080/19420862.2022.2026208. MAbs. 2022. PMID: 35075980 Free PMC article.

6

DeepSP: Deep learning-based spatial properties to predict monoclonal antibody stability.

Kalejaye L, Wu IE, Terry T, Lai PK. Kalejaye L, et al. Among authors: lai pk. Comput Struct Biotechnol J. 2024 May 18;23:2220-2229. doi: 10.1016/j.csbj.2024.05.029. eCollection 2024 Dec. Comput Struct Biotechnol J. 2024. PMID: 38827232 Free PMC article.

7

DeepSCM: An efficient convolutional neural network surrogate model for the screening of therapeutic antibody viscosity.

Lai PK. Lai PK. Comput Struct Biotechnol J. 2022 Apr 29;20:2143-2152. doi: 10.1016/j.csbj.2022.04.035. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 35832619 Free PMC article.

8

Teaching biologics design using molecular modeling and simulations.

Phillips A, Srinivas A, Prentoska I, O'Dea M, Kustrup M, Hurley S, Bruno S, Nguyen V, Lai PK. Phillips A, et al. Among authors: lai pk. Biochem Mol Biol Educ. 2024 May-Jun;52(3):299-310. doi: 10.1002/bmb.21813. Epub 2024 Jan 10. Biochem Mol Biol Educ. 2024. PMID: 38197506

9

Determination of Metabolic Fluxes by Deep Learning of Isotope Labeling Patterns.

Law RC, O'Keeffe S, Nurwono G, Ki R, Lakhani A, Lai PK, Park JO. Law RC, et al. Among authors: lai pk. bioRxiv [Preprint]. 2023 Nov 8:2023.11.06.565907. doi: 10.1101/2023.11.06.565907. bioRxiv. 2023. PMID: 37986781 Free PMC article. Preprint.

10

Coarse-grained modeling of protein second osmotic virial coefficients: sterics and short-ranged attractions.

Grünberger A, Lai PK, Blanco MA, Roberts CJ. Grünberger A, et al. Among authors: lai pk. J Phys Chem B. 2013 Jan 24;117(3):763-70. doi: 10.1021/jp308234j. Epub 2013 Jan 10. J Phys Chem B. 2013. PMID: 23245189

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