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Development of an LC-MS/MS method for quantifying ASK120067, a novel mutant-selective inhibitor of the epidermal growth factor receptor (EGFR) as well as its main metabolite in human plasma and its application in a pharmacokinetic study.
Cui X, Wang S, Gao H, Li B, Shi Y, Guo H, Song T, Zheng X. Cui X, et al. Among authors: guo h. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jan 1;1162:122488. doi: 10.1016/j.jchromb.2020.122488. Epub 2020 Dec 7. J Chromatogr B Analyt Technol Biomed Life Sci. 2021. PMID: 33360679 Clinical Trial.
Phase 1 study to evaluate the effects of rifampin or itraconazole on the pharmacokinetics of limertinib (ASK120067), a novel mutant-selective inhibitor of the epidermal growth factor receptor in healthy Chinese subjects.
Cao B, Huang L, Liu M, Lin H, Ma T, Zhao Y, Geng Y, Yang Y, Guo H, Li J. Cao B, et al. Among authors: guo h. Expert Opin Drug Metab Toxicol. 2023 Sep;19(9):653-664. doi: 10.1080/17425255.2023.2260738. Epub 2023 Oct 12. Expert Opin Drug Metab Toxicol. 2023. PMID: 37811634 Clinical Trial.
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