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In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N-Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis.
Silva DKC, Teixeira JS, Moreira DRM, da Silva TF, Barreiro EJL, de Freitas HF, Pita SSDR, Teles ALB, Guimarães ET, Soares MBP. Silva DKC, et al. Among authors: barreiro ejl. Front Pharmacol. 2020 Dec 16;11:590544. doi: 10.3389/fphar.2020.590544. eCollection 2020. Front Pharmacol. 2020. PMID: 33390966 Free PMC article.
LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice.
Silva JC, Oliveira Júnior RG, Silva MGE, Lavor ÉM, Soares JMD, Lima-Saraiva SRG, Diniz TC, Mendes RL, Alencar Filho EB, Barreiro EJL, Lima LM, Almeida JRGDS. Silva JC, et al. Among authors: barreiro ejl. PLoS One. 2018 Jul 30;13(7):e0199009. doi: 10.1371/journal.pone.0199009. eCollection 2018. PLoS One. 2018. PMID: 30059558 Free PMC article.
In vitro results with minimal blood toxicity of a combretastatin A4 analogue.
Chagas C, Mansano JV, da Silva EB, Petri G, da Costa Aguiar Alves Reis B, Schumacher ML, Haddad PS, Pereira EC, Britos TN, Barreiro EJ, Lima LM, Ferreira FF, Fonseca FLA. Chagas C, et al. Invest New Drugs. 2024 Jun;42(3):318-325. doi: 10.1007/s10637-024-01440-4. Epub 2024 May 17. Invest New Drugs. 2024. PMID: 38758478