Kerns RJ - Search Results

1

A Novel Triphenylphosphonium Carrier to Target Mitochondria without Uncoupling Oxidative Phosphorylation.

Kulkarni CA, Fink BD, Gibbs BE, Chheda PR, Wu M, Sivitz WI, Kerns RJ. Kulkarni CA, et al. Among authors: kerns rj. J Med Chem. 2021 Jan 14;64(1):662-676. doi: 10.1021/acs.jmedchem.0c01671. Epub 2021 Jan 4. J Med Chem. 2021. PMID: 33395531 Free PMC article.

2

Structural features of piperazinyl-linked ciprofloxacin dimers required for activity against drug-resistant strains of Staphylococcus aureus.

Kerns RJ, Rybak MJ, Kaatz GW, Vaka F, Cha R, Grucz RG, Diwadkar VU. Kerns RJ, et al. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2109-12. doi: 10.1016/s0960-894x(03)00376-7. Bioorg Med Chem Lett. 2003. PMID: 12798315

3

Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps.

German N, Wei P, Kaatz GW, Kerns RJ. German N, et al. Among authors: kerns rj. Eur J Med Chem. 2008 Nov;43(11):2453-63. doi: 10.1016/j.ejmech.2008.01.042. Epub 2008 Feb 8. Eur J Med Chem. 2008. PMID: 18358571

4

Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells.

Fink BD, Herlein JA, Yorek MA, Fenner AM, Kerns RJ, Sivitz WI. Fink BD, et al. Among authors: kerns rj. J Pharmacol Exp Ther. 2012 Sep;342(3):709-19. doi: 10.1124/jpet.112.195586. Epub 2012 Jun 1. J Pharmacol Exp Ther. 2012. PMID: 22661629 Free PMC article.

5

A mitochondrial-targeted coenzyme q analog prevents weight gain and ameliorates hepatic dysfunction in high-fat-fed mice.

Fink BD, Herlein JA, Guo DF, Kulkarni C, Weidemann BJ, Yu L, Grobe JL, Rahmouni K, Kerns RJ, Sivitz WI. Fink BD, et al. Among authors: kerns rj. J Pharmacol Exp Ther. 2014 Dec;351(3):699-708. doi: 10.1124/jpet.114.219329. Epub 2014 Oct 9. J Pharmacol Exp Ther. 2014. PMID: 25301169 Free PMC article.

6

Metabolic effects of a mitochondrial-targeted coenzyme Q analog in high fat fed obese mice.

Fink BD, Guo DF, Kulkarni CA, Rahmouni K, Kerns RJ, Sivitz WI. Fink BD, et al. Among authors: kerns rj. Pharmacol Res Perspect. 2017 Mar 10;5(2):e00301. doi: 10.1002/prp2.301. eCollection 2017 Apr. Pharmacol Res Perspect. 2017. PMID: 28357127 Free PMC article.

7

Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase.

Towle TR, Kulkarni CA, Oppegard LM, Williams BP, Picha TA, Hiasa H, Kerns RJ. Towle TR, et al. Among authors: kerns rj. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1903-1910. doi: 10.1016/j.bmcl.2018.03.085. Epub 2018 Mar 30. Bioorg Med Chem Lett. 2018. PMID: 29661533 Free PMC article.

8

Effect of a mitochondrial-targeted coenzyme Q analog on pancreatic β-cell function and energetics in high fat fed obese mice.

Imai Y, Fink BD, Promes JA, Kulkarni CA, Kerns RJ, Sivitz WI. Imai Y, et al. Among authors: kerns rj. Pharmacol Res Perspect. 2018 Jun;6(3):e00393. doi: 10.1002/prp2.393. Epub 2018 May 18. Pharmacol Res Perspect. 2018. PMID: 29864244 Free PMC article.

9

Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity.

Oppegard LM, Delgado JL, Kulkarni CA, Towle TR, Hart DE, Williams BP, Lentz SRC, Norris BJ, Flory CM, Schumacher RJ, Murry DJ, Kerns RJ, Hiasa H. Oppegard LM, et al. Among authors: kerns rj. Invest New Drugs. 2019 Apr;37(2):378-383. doi: 10.1007/s10637-018-0666-x. Epub 2018 Sep 10. Invest New Drugs. 2019. PMID: 30198058 Free PMC article.

10

The C7-aminomethylpyrrolidine group rescues the activity of a thio-fluoroquinolone.

Lentz SRC, Chheda PR, Oppegard LM, Towle TR, Kerns RJ, Hiasa H. Lentz SRC, et al. Among authors: kerns rj. Biochimie. 2019 May;160:24-27. doi: 10.1016/j.biochi.2019.02.002. Epub 2019 Feb 11. Biochimie. 2019. PMID: 30763638 Free PMC article.

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