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Replication Protein A Presents Canonical Functions and Is Also Involved in the Differentiation Capacity of Trypanosoma cruzi.
Pavani RS, da Silva MS, Fernandes CA, Morini FS, Araujo CB, Fontes MR, Sant'Anna OA, Machado CR, Cano MI, Fragoso SP, Elias MC. Pavani RS, et al. Among authors: machado cr. PLoS Negl Trop Dis. 2016 Dec 16;10(12):e0005181. doi: 10.1371/journal.pntd.0005181. eCollection 2016 Dec. PLoS Negl Trop Dis. 2016. PMID: 27984589 Free PMC article.
The recombinase Rad51 plays a key role in events of genetic exchange in Trypanosoma cruzi.
Alves CL, Repolês BM, da Silva MS, Mendes IC, Marin PA, Aguiar PHN, Santos SDS, Franco GR, Macedo AM, Pena SDJ, Andrade LO, Guarneri AA, Tahara EB, Elias MC, Machado CR. Alves CL, et al. Among authors: machado cr. Sci Rep. 2018 Sep 6;8(1):13335. doi: 10.1038/s41598-018-31541-z. Sci Rep. 2018. PMID: 30190603 Free PMC article.
DNA Topoisomerase 3α Is Involved in Homologous Recombination Repair and Replication Stress Response in Trypanosoma cruzi.
Costa-Silva HM, Resende BC, Umaki ACS, Prado W, da Silva MS, Virgílio S, Macedo AM, Pena SDJ, Tahara EB, Tosi LRO, Elias MC, Andrade LO, Reis-Cunha JL, Franco GR, Fragoso SP, Machado CR. Costa-Silva HM, et al. Among authors: machado cr. Front Cell Dev Biol. 2021 May 13;9:633195w. doi: 10.3389/fcell.2021.633195. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34055812 Free PMC article.
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops.
Mendes IC, Dos Reis Bertoldo W, Miranda-Junior AS, Assis AV, Repolês BM, Ferreira WRR, Chame DF, Souza DL, Pavani RS, Macedo AM, Franco GR, Serra E, Perdomo V, Menck CFM, da Silva Leandro G, Fragoso SP, Barbosa Elias MCQ, Machado CR. Mendes IC, et al. Among authors: machado cr. DNA Repair (Amst). 2024 Sep;141:103726. doi: 10.1016/j.dnarep.2024.103726. Epub 2024 Jul 27. DNA Repair (Amst). 2024. PMID: 39096697
212 results