Caffrey CR - Search Results

1

A Machine Learning Strategy for Drug Discovery Identifies Anti-Schistosomal Small Molecules.

Zorn KM, Sun S, McConnon CL, Ma K, Chen EK, Foil DH, Lane TR, Liu LJ, El-Sakkary N, Skinner DE, Ekins S, Caffrey CR. Zorn KM, et al. Among authors: caffrey cr. ACS Infect Dis. 2021 Feb 12;7(2):406-420. doi: 10.1021/acsinfecdis.0c00754. Epub 2021 Jan 12. ACS Infect Dis. 2021. PMID: 33434015 Free PMC article.

2

A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni.

Caffrey CR, Rohwer A, Oellien F, Marhöfer RJ, Braschi S, Oliveira G, McKerrow JH, Selzer PM. Caffrey CR, et al. PLoS One. 2009;4(2):e4413. doi: 10.1371/journal.pone.0004413. Epub 2009 Feb 9. PLoS One. 2009. PMID: 19198654 Free PMC article.

3

Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.

Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA Jr, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR. Long T, et al. Among authors: caffrey cr. PLoS Negl Trop Dis. 2017 Jul 13;11(7):e0005680. doi: 10.1371/journal.pntd.0005680. eCollection 2017 Jul. PLoS Negl Trop Dis. 2017. PMID: 28704396 Free PMC article.

4

Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development.

El-Sakkary N, Chen S, Arkin MR, Caffrey CR, Ribeiro P. El-Sakkary N, et al. Among authors: caffrey cr. Dis Model Mech. 2018 Jul 30;11(7):dmm033563. doi: 10.1242/dmm.033563. Dis Model Mech. 2018. PMID: 29925529 Free PMC article.

5

High Throughput and Computational Repurposing for Neglected Diseases.

Hernandez HW, Soeung M, Zorn KM, Ashoura N, Mottin M, Andrade CH, Caffrey CR, de Siqueira-Neto JL, Ekins S. Hernandez HW, et al. Among authors: caffrey cr. Pharm Res. 2018 Dec 17;36(2):27. doi: 10.1007/s11095-018-2558-3. Pharm Res. 2018. PMID: 30560386 Free PMC article. Review.

6

Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment.

Zhang S, Skinner D, Joshi P, Criado-Hidalgo E, Yeh YT, Lasheras JC, Caffrey CR, Del Alamo JC. Zhang S, et al. Among authors: caffrey cr. J R Soc Interface. 2019 Jan 31;16(150):20180675. doi: 10.1098/rsif.2018.0675. J R Soc Interface. 2019. PMID: 30958153 Free PMC article.

7

Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni.

Probst A, Nguyen TN, El-Sakkary N, Skinner D, Suzuki BM, Buckner FS, Gelb MH, Caffrey CR, Debnath A. Probst A, et al. Among authors: caffrey cr. Front Cell Infect Microbiol. 2019 May 29;9:180. doi: 10.3389/fcimb.2019.00180. eCollection 2019. Front Cell Infect Microbiol. 2019. PMID: 31192168 Free PMC article.

8

The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni.

Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki BM, El-Sakkary N, Hook V, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. Bibo-Verdugo B, et al. Among authors: caffrey cr. ACS Infect Dis. 2019 Oct 11;5(10):1802-1812. doi: 10.1021/acsinfecdis.9b00237. Epub 2019 Aug 12. ACS Infect Dis. 2019. PMID: 31355632 Free PMC article.

9

Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery.

Maccesi M, Aguiar PHN, Pasche V, Padilla M, Suzuki BM, Montefusco S, Abagyan R, Keiser J, Mourão MM, Caffrey CR. Maccesi M, et al. Among authors: caffrey cr. Parasit Vectors. 2019 Oct 22;12(1):493. doi: 10.1186/s13071-019-3747-6. Parasit Vectors. 2019. PMID: 31640761 Free PMC article.

10

Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty.

Singh S, El-Sakkary N, Skinner DE, Sharma PP, Ottilie S, Antonova-Koch Y, Kumar P, Winzeler E, Poonam, Caffrey CR, Rathi B. Singh S, et al. Among authors: caffrey cr. Pharmaceuticals (Basel). 2020 Feb 3;13(2):25. doi: 10.3390/ph13020025. Pharmaceuticals (Basel). 2020. PMID: 32028743 Free PMC article.

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