Nies AT - Search Results

1

Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins.

Neul C, Hofmann U, Schaeffeler E, Winter S, Klein K, Giacomini KM, Eichelbaum M, Schwab M, Nies AT. Neul C, et al. Among authors: nies at. Br J Pharmacol. 2021 Mar;178(6):1459-1474. doi: 10.1111/bph.15370. Epub 2021 Feb 23. Br J Pharmacol. 2021. PMID: 33434947 Free article.

2

A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter.

Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM, Klein K, Eichelbaum M, Keppler D, Konig J. Michalski C, et al. Among authors: nies at. J Biol Chem. 2002 Nov 8;277(45):43058-63. doi: 10.1074/jbc.M207735200. Epub 2002 Aug 23. J Biol Chem. 2002. PMID: 12196548 Free article.

3

Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs.

Nies AT, Schwab M, Keppler D. Nies AT, et al. Expert Opin Drug Metab Toxicol. 2008 May;4(5):545-68. doi: 10.1517/17425255.4.5.545. Expert Opin Drug Metab Toxicol. 2008. PMID: 18484914 Review.

4

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.

Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, Zanger UM, Keppler D, Schwab M, Schaeffeler E. Nies AT, et al. Hepatology. 2009 Oct;50(4):1227-40. doi: 10.1002/hep.23103. Hepatology. 2009. PMID: 19591196

5

Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.

Nies AT, Koepsell H, Damme K, Schwab M. Nies AT, et al. Handb Exp Pharmacol. 2011;(201):105-67. doi: 10.1007/978-3-642-14541-4_3. Handb Exp Pharmacol. 2011. PMID: 21103969 Review.

6

Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs).

Nies AT, Hofmann U, Resch C, Schaeffeler E, Rius M, Schwab M. Nies AT, et al. PLoS One. 2011;6(7):e22163. doi: 10.1371/journal.pone.0022163. Epub 2011 Jul 14. PLoS One. 2011. PMID: 21779389 Free PMC article.

7

Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics.

Damme K, Nies AT, Schaeffeler E, Schwab M. Damme K, et al. Among authors: nies at. Drug Metab Rev. 2011 Nov;43(4):499-523. doi: 10.3109/03602532.2011.602687. Epub 2011 Sep 17. Drug Metab Rev. 2011. PMID: 21923552 Review.

8

Organic cation transporter pharmacogenomics and drug-drug interaction.

Nies AT, Schwab M. Nies AT, et al. Expert Rev Clin Pharmacol. 2010 Nov;3(6):707-11. doi: 10.1586/ecp.10.60. Expert Rev Clin Pharmacol. 2010. PMID: 22111772 No abstract available.

9

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma.

Schaeffeler E, Hellerbrand C, Nies AT, Winter S, Kruck S, Hofmann U, van der Kuip H, Zanger UM, Koepsell H, Schwab M. Schaeffeler E, et al. Among authors: nies at. Genome Med. 2011 Dec 23;3(12):82. doi: 10.1186/gm298. Genome Med. 2011. PMID: 22196450 Free PMC article.

10

Human pregnane X receptor genotype of the donor but not of the recipient is a risk factor for delayed graft function after renal transplantation.

Hauser IA, Kruck S, Gauer S, Nies AT, Winter S, Bedke J, Geiger H, Hoefeld H, Kleemann J, Asbe-Vollkopf A, Engel J, Burk O, Schwab M, Schaeffeler E. Hauser IA, et al. Among authors: nies at. Clin Pharmacol Ther. 2012 May;91(5):905-16. doi: 10.1038/clpt.2011.346. Epub 2012 Mar 28. Clin Pharmacol Ther. 2012. PMID: 22453193

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