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Page 1
Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
Ellwanger DC, Wang S, Brioschi S, Shao Z, Green L, Case R, Yoo D, Weishuhn D, Rathanaswami P, Bradley J, Rao S, Cha D, Luan P, Sambashivan S, Gilfillan S, Hasson SA, Foltz IN, van Lookeren Campagne M, Colonna M. Ellwanger DC, et al. Among authors: sambashivan s. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2017742118. doi: 10.1073/pnas.2017742118. Proc Natl Acad Sci U S A. 2021. PMID: 33446504 Free PMC article.
TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function.
Cheng Q, Danao J, Talreja S, Wen P, Yin J, Sun N, Li CM, Chui D, Tran D, Koirala S, Chen H, Foltz IN, Wang S, Sambashivan S. Cheng Q, et al. Among authors: sambashivan s. J Biol Chem. 2018 Aug 10;293(32):12620-12633. doi: 10.1074/jbc.RA118.001848. Epub 2018 Mar 29. J Biol Chem. 2018. PMID: 29599291 Free PMC article.
Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
Sudom A, Talreja S, Danao J, Bragg E, Kegel R, Min X, Richardson J, Zhang Z, Sharkov N, Marcora E, Thibault S, Bradley J, Wood S, Lim AC, Chen H, Wang S, Foltz IN, Sambashivan S, Wang Z. Sudom A, et al. Among authors: sambashivan s. J Biol Chem. 2018 Aug 10;293(32):12634-12646. doi: 10.1074/jbc.RA118.002352. Epub 2018 May 24. J Biol Chem. 2018. PMID: 29794134 Free PMC article.
Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease.
Bratkowski M, Burdett TC, Danao J, Wang X, Mathur P, Gu W, Beckstead JA, Talreja S, Yang YS, Danko G, Park JH, Walton M, Brown SP, Tegley CM, Joseph PRB, Reynolds CH, Sambashivan S. Bratkowski M, et al. Among authors: sambashivan s. Neuron. 2022 Nov 16;110(22):3711-3726.e16. doi: 10.1016/j.neuron.2022.08.017. Epub 2022 Sep 9. Neuron. 2022. PMID: 36087583 Free article.
Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1.
Bratkowski M, Xie T, Thayer DA, Lad S, Mathur P, Yang YS, Danko G, Burdett TC, Danao J, Cantor A, Kozak JA, Brown SP, Bai X, Sambashivan S. Bratkowski M, et al. Among authors: sambashivan s. Cell Rep. 2020 Aug 4;32(5):107999. doi: 10.1016/j.celrep.2020.107999. Cell Rep. 2020. PMID: 32755591 Free article.
SARM1 signaling mechanisms in the injured nervous system.
Sambashivan S, Freeman MR. Sambashivan S, et al. Curr Opin Neurobiol. 2021 Aug;69:247-255. doi: 10.1016/j.conb.2021.05.004. Epub 2021 Jun 25. Curr Opin Neurobiol. 2021. PMID: 34175654 Free PMC article. Review.
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