Yang CH - Search Results

1

Adaptive resistance to PI3Kα-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells.

Wang YX, Zhang X, Ma QY, Hu LD, Zhang X, Wang Y, Xu L, Yang CH, Tan C, Kong XY, Ding J, Meng LH. Wang YX, et al. Among authors: yang ch. Cell Death Dis. 2021 Jan 14;12(1):85. doi: 10.1038/s41419-020-03370-4. Cell Death Dis. 2021. PMID: 33446653 Free PMC article.

2

Novel indole alpha-methylene-gamma-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases.

Ding H, Zhang C, Wu X, Yang C, Zhang X, Ding J, Xie Y. Ding H, et al. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4799-802. doi: 10.1016/j.bmcl.2005.07.050. Bioorg Med Chem Lett. 2005. PMID: 16143526

3

Synthesis and activity of Combretastatin A-4 analogues: 1,2,3-thiadiazoles as potent antitumor agents.

Wu M, Sun Q, Yang C, Chen D, Ding J, Chen Y, Lin L, Xie Y. Wu M, et al. Bioorg Med Chem Lett. 2007 Feb 15;17(4):869-73. doi: 10.1016/j.bmcl.2006.11.060. Epub 2006 Nov 29. Bioorg Med Chem Lett. 2007. PMID: 17174089

4

S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton.

Zhang C, Yang N, Yang CH, Ding HS, Luo C, Zhang Y, Wu MJ, Zhang XW, Shen X, Jiang HL, Meng LH, Ding J. Zhang C, et al. Among authors: yang ch, yang n. PLoS One. 2009;4(3):e4881. doi: 10.1371/journal.pone.0004881. Epub 2009 Mar 18. PLoS One. 2009. PMID: 19293927 Free PMC article.

5

Direct palladium-catalyzed arylations of aryl bromides with 2/9-substituted pyrimido[5,4-b]indolizines.

Jiang M, Li T, Meng L, Yang C, Xie Y, Ding J. Jiang M, et al. J Comb Chem. 2009 Sep-Oct;11(5):806-8. doi: 10.1021/cc800162k. J Comb Chem. 2009. PMID: 19645499

6

WJD008, a dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant.

Li T, Wang J, Wang X, Yang N, Chen SM, Tong LJ, Yang CH, Meng LH, Ding J. Li T, et al. Among authors: yang ch, yang n. J Pharmacol Exp Ther. 2010 Sep 1;334(3):830-8. doi: 10.1124/jpet.110.167940. Epub 2010 Jun 3. J Pharmacol Exp Ther. 2010. PMID: 20522531

7

Design, synthesis and biological evaluation of substituted 11H-benzo[a]carbazole-5-carboxamides as novel antitumor agents.

Wang YQ, Li XH, He Q, Chen Y, Xie YY, Ding J, Miao ZH, Yang CH. Wang YQ, et al. Among authors: yang ch. Eur J Med Chem. 2011 Dec;46(12):5878-84. doi: 10.1016/j.ejmech.2011.09.050. Epub 2011 Oct 4. Eur J Med Chem. 2011. PMID: 22000922

8

Discovery and bioactivity of 4-(2-arylpyrido[3',2':3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitors.

Wang J, Wang X, Chen Y, Chen S, Chen G, Tong L, Meng L, Xie Y, Ding J, Yang C. Wang J, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):339-42. doi: 10.1016/j.bmcl.2011.11.003. Epub 2011 Nov 9. Bioorg Med Chem Lett. 2012. PMID: 22130133

9

A novel convenient approach towards pyrrolo[1,2-b]pyridazines through a domino coupling-isomerization-condensation reaction.

Wang M, Tan C, He Q, Xie Y, Yang C. Wang M, et al. Org Biomol Chem. 2013 Apr 28;11(16):2574-7. doi: 10.1039/c3ob40157j. Org Biomol Chem. 2013. PMID: 23487245

10

Natural product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents.

Liang YK, Yue ZZ, Li JX, Tan C, Miao ZH, Tan WF, Yang CH. Liang YK, et al. Among authors: yang ch. Eur J Med Chem. 2014 Sep 12;84:505-15. doi: 10.1016/j.ejmech.2014.07.047. Epub 2014 Jul 15. Eur J Med Chem. 2014. PMID: 25050882

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