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Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko M, Mikuda N, Höpken UE, Kärgel E, Uyar B, Tufan AB, Milanovic M, Sun W, Krahn I, Schleich K, von Hoff L, Hinz M, Willenbrock M, Jungmann S, Akalin A, Lee S, Schmidt-Ullrich R, Schmitt CA, Scheidereit C. Kolesnichenko M, et al. Among authors: tufan ab. EMBO J. 2021 Mar 15;40(6):e104296. doi: 10.15252/embj.2019104296. Epub 2021 Jan 18. EMBO J. 2021. PMID: 33459422 Free PMC article.
The IκB kinase complex is a regulator of mRNA stability.
Mikuda N, Kolesnichenko M, Beaudette P, Popp O, Uyar B, Sun W, Tufan AB, Perder B, Akalin A, Chen W, Mertins P, Dittmar G, Hinz M, Scheidereit C. Mikuda N, et al. Among authors: tufan ab. EMBO J. 2018 Dec 14;37(24):e98658. doi: 10.15252/embj.201798658. Epub 2018 Nov 22. EMBO J. 2018. PMID: 30467221 Free PMC article.
Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity.
Fontana P, Du G, Zhang Y, Zhang H, Vora SM, Hu JJ, Shi M, Tufan AB, Healy LB, Xia S, Lee DJ, Li Z, Baldominos P, Ru H, Luo HR, Agudo J, Lieberman J, Wu H. Fontana P, et al. Among authors: tufan ab. Cell. 2024 Oct 31;187(22):6165-6181.e22. doi: 10.1016/j.cell.2024.08.007. Epub 2024 Sep 6. Cell. 2024. PMID: 39243763