Tervonen TA - Search Results

1

Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin.

Tervonen TA, Pant SM, Belitškin D, Englund JI, Närhi K, Haglund C, Kovanen PE, Verschuren EW, Klefström J. Tervonen TA, et al. Cancer Res. 2021 Mar 15;81(6):1513-1527. doi: 10.1158/0008-5472.CAN-20-1760. Epub 2021 Jan 18. Cancer Res. 2021. PMID: 33461973

2

Faulty epithelial polarity genes and cancer.

Tervonen TA, Partanen JI, Saarikoski ST, Myllynen M, Marques E, Paasonen K, Moilanen A, Wohlfahrt G, Kovanen PE, Klefstrom J. Tervonen TA, et al. Adv Cancer Res. 2011;111:97-161. doi: 10.1016/B978-0-12-385524-4.00003-9. Adv Cancer Res. 2011. PMID: 21704831 Review.

3

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity.

Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J. Partanen JI, et al. Among authors: tervonen ta. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):E388-97. doi: 10.1073/pnas.1120421109. Epub 2012 Jan 20. Proc Natl Acad Sci U S A. 2012. PMID: 22308451 Free PMC article.

4

Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis.

Nieminen AI, Eskelinen VM, Haikala HM, Tervonen TA, Yan Y, Partanen JI, Klefström J. Nieminen AI, et al. Among authors: tervonen ta. Proc Natl Acad Sci U S A. 2013 May 14;110(20):E1839-48. doi: 10.1073/pnas.1208530110. Epub 2013 Apr 15. Proc Natl Acad Sci U S A. 2013. PMID: 23589839 Free PMC article.

5

Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4.

Partanen JI, Tervonen TA, Klefström J. Partanen JI, et al. Among authors: tervonen ta. Philos Trans R Soc Lond B Biol Sci. 2013 Sep 23;368(1629):20130111. doi: 10.1098/rstb.2013.0111. Print 2013. Philos Trans R Soc Lond B Biol Sci. 2013. PMID: 24062587 Free PMC article. Review.

6

Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers.

Marques E, Englund JI, Tervonen TA, Virkunen E, Laakso M, Myllynen M, Mäkelä A, Ahvenainen M, Lepikhova T, Monni O, Hautaniemi S, Klefström J. Marques E, et al. Among authors: tervonen ta. Oncogene. 2016 Mar 17;35(11):1386-98. doi: 10.1038/onc.2015.196. Epub 2015 Jun 15. Oncogene. 2016. PMID: 26073086 Free PMC article.

7

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.

Tervonen TA, Belitškin D, Pant SM, Englund JI, Marques E, Ala-Hongisto H, Nevalaita L, Sihto H, Heikkilä P, Leidenius M, Hewitson K, Ramachandra M, Moilanen A, Joensuu H, Kovanen PE, Poso A, Klefström J. Tervonen TA, et al. Oncogene. 2016 Apr 7;35(14):1832-46. doi: 10.1038/onc.2015.248. Epub 2015 Jul 13. Oncogene. 2016. PMID: 26165838

8

Analyzing the Type II Transmembrane Serine Protease Hepsin-Dependent Basement Membrane Remodeling in 3D Cell Culture.

Pant SM, Belitskin D, Ala-Hongisto H, Klefström J, Tervonen TA. Pant SM, et al. Among authors: tervonen ta. Methods Mol Biol. 2018;1731:169-178. doi: 10.1007/978-1-4939-7595-2_16. Methods Mol Biol. 2018. PMID: 29318553

9

Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform.

Pant SM, Mukonoweshuro A, Desai B, Ramjee MK, Selway CN, Tarver GJ, Wright AG, Birchall K, Chapman TM, Tervonen TA, Klefström J. Pant SM, et al. Among authors: tervonen ta. J Med Chem. 2018 May 24;61(10):4335-4347. doi: 10.1021/acs.jmedchem.7b01698. Epub 2018 May 14. J Med Chem. 2018. PMID: 29701962

10

Hepsin regulates TGFβ signaling via fibronectin proteolysis.

Belitškin D, Pant SM, Munne P, Suleymanova I, Belitškina K, Hongisto HA, Englund J, Raatikainen T, Klezovitch O, Vasioukhin V, Li S, Wu Q, Monni O, Kuure S, Laakkonen P, Pouwels J, Tervonen TA, Klefström J. Belitškin D, et al. Among authors: tervonen ta. EMBO Rep. 2021 Nov 4;22(11):e52532. doi: 10.15252/embr.202152532. Epub 2021 Sep 13. EMBO Rep. 2021. PMID: 34515392 Free PMC article.

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