Pointon A - Search Results

1

Cardiovascular microphysiological systems (CVMPS) for safety studies - a pharma perspective.

Pointon A, Maher J, Davis M, Baker T, Cichocki J, Ramsden D, Hale C, Kolaja KL, Levesque P, Sura R, Stresser DM, Gintant G. Pointon A, et al. Lab Chip. 2021 Feb 9;21(3):458-472. doi: 10.1039/d0lc01040e. Lab Chip. 2021. PMID: 33471007

2

Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.

Vargas HM, Rolf MG, Wisialowski TA, Achanzar W, Bahinski A, Bass A, Benson CT, Chaudhary KW, Couvreur N, Dota C, Engwall MJ, Michael Foley C, Gallacher D, Greiter-Wilke A, Guillon JM, Guth B, Himmel HM, Hegele-Hartung C, Ito M, Jenkinson S, Chiba K, Lagrutta A, Levesque P, Martel E, Okai Y, Peri R, Pointon A, Qu Y, Teisman A, Traebert M, Yoshinaga T, Gintant GA, Leishman DJ, Valentin JP. Vargas HM, et al. Among authors: pointon a. Clin Pharmacol Ther. 2021 Feb;109(2):310-318. doi: 10.1002/cpt.2029. Epub 2020 Sep 24. Clin Pharmacol Ther. 2021. PMID: 32866317 Free PMC article. Review.

3

Assessment of cardiomyocyte contraction in human-induced pluripotent stem cell-derived cardiomyocytes.

Pointon A, Harmer AR, Dale IL, Abi-Gerges N, Bowes J, Pollard C, Garside H. Pointon A, et al. Toxicol Sci. 2015 Apr;144(2):227-37. doi: 10.1093/toxsci/kfu312. Epub 2014 Dec 22. Toxicol Sci. 2015. PMID: 25538221

4

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues.

Ravenscroft SM, Pointon A, Williams AW, Cross MJ, Sidaway JE. Ravenscroft SM, et al. Among authors: pointon a. Toxicol Sci. 2016 Jul;152(1):99-112. doi: 10.1093/toxsci/kfw069. Epub 2016 Apr 28. Toxicol Sci. 2016. PMID: 27125969 Free PMC article.

5

Assessment of extracellular field potential and Ca²⁺ transient signals for early QT/pro-arrhythmia detection using human induced pluripotent stem cell-derived cardiomyocytes.

Abi-Gerges N, Pointon A, Oldman KL, Brown MR, Pilling MA, Sefton CE, Garside H, Pollard CE. Abi-Gerges N, et al. Among authors: pointon a. J Pharmacol Toxicol Methods. 2017 Jan-Feb;83:1-15. doi: 10.1016/j.vascn.2016.09.001. Epub 2016 Sep 10. J Pharmacol Toxicol Methods. 2017. PMID: 27622857

6

From the Cover: High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery.

Pointon A, Pilling J, Dorval T, Wang Y, Archer C, Pollard C. Pointon A, et al. Toxicol Sci. 2017 Feb;155(2):444-457. doi: 10.1093/toxsci/kfw227. Epub 2016 Nov 15. Toxicol Sci. 2017. PMID: 28069985

7

Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology.

Archer CR, Sargeant R, Basak J, Pilling J, Barnes JR, Pointon A. Archer CR, et al. Among authors: pointon a. Sci Rep. 2018 Jul 5;8(1):10160. doi: 10.1038/s41598-018-28393-y. Sci Rep. 2018. PMID: 29976997 Free PMC article.

8

Current and future approaches to nonclinical cardiovascular safety assessment.

Collins TA, Rolf MG, Pointon A. Collins TA, et al. Among authors: pointon a. Drug Discov Today. 2020 Jul;25(7):1129-1134. doi: 10.1016/j.drudis.2020.03.011. Epub 2020 Mar 21. Drug Discov Today. 2020. PMID: 32209428 Free article.

9

Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning.

Yang H, Stebbeds W, Francis J, Pointon A, Obrezanova O, Beattie KA, Clements P, Harvey JS, Smith GF, Bender A. Yang H, et al. Among authors: pointon a. Stem Cell Reports. 2022 Mar 8;17(3):556-568. doi: 10.1016/j.stemcr.2022.01.009. Epub 2022 Feb 10. Stem Cell Reports. 2022. PMID: 35148844 Free PMC article.

10

Application of microphysiological systems for nonclinical evaluation of cell therapies.

Candarlioglu PL, Delsing L, Gauthier L, Lewis L, Papadopoulos G, Freag M, Chan TS, Homan KA, Fellows MD, Pointon A, Kojala K. Candarlioglu PL, et al. Among authors: pointon a. ALTEX. 2024;41(3):469-484. doi: 10.14573/altex.2402201. Epub 2024 May 15. ALTEX. 2024. PMID: 38746991 Free article. Review.

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