Kelly JW - Search Results

1

Does protein aggregation drive postmitotic tissue degeneration?

Kelly JW. Kelly JW. Sci Transl Med. 2021 Jan 20;13(577):eaax0914. doi: 10.1126/scitranslmed.aax0914. Sci Transl Med. 2021. PMID: 33472954 Free PMC article. Review.

2

Amyloid diseases: abnormal protein aggregation in neurodegeneration.

Koo EH, Lansbury PT Jr, Kelly JW. Koo EH, et al. Among authors: kelly jw. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):9989-90. doi: 10.1073/pnas.96.18.9989. Proc Natl Acad Sci U S A. 1999. PMID: 10468546 Free PMC article. Review. No abstract available.

3

A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis.

Bieschke J, Cohen E, Murray A, Dillin A, Kelly JW. Bieschke J, et al. Among authors: kelly jw. Protein Sci. 2009 Nov;18(11):2231-41. doi: 10.1002/pro.234. Protein Sci. 2009. PMID: 19701939 Free PMC article.

4

Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity.

Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW. Usui K, et al. Among authors: kelly jw. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18563-8. doi: 10.1073/pnas.0804758106. Epub 2009 Oct 19. Proc Natl Acad Sci U S A. 2009. PMID: 19841277 Free PMC article.

5

Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.

Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA. Alhamadsheh MM, et al. Among authors: kelly jw. Sci Transl Med. 2011 Aug 24;3(97):97ra81. doi: 10.1126/scitranslmed.3002473. Sci Transl Med. 2011. PMID: 21865539 Free PMC article.

6

The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.

Johnson SM, Connelly S, Fearns C, Powers ET, Kelly JW. Johnson SM, et al. Among authors: kelly jw. J Mol Biol. 2012 Aug 10;421(2-3):185-203. doi: 10.1016/j.jmb.2011.12.060. Epub 2012 Jan 5. J Mol Biol. 2012. PMID: 22244854 Free PMC article. Review.

7

Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro.

Li X, Zhang X, Ladiwala AR, Du D, Yadav JK, Tessier PM, Wright PE, Kelly JW, Buxbaum JN. Li X, et al. Among authors: kelly jw. J Neurosci. 2013 Dec 11;33(50):19423-33. doi: 10.1523/JNEUROSCI.2561-13.2013. J Neurosci. 2013. PMID: 24336709 Free PMC article.

8

Immunoprecipitation of amyloid fibrils by the use of an antibody that recognizes a generic epitope common to amyloid fibrils.

Greiner ER, Kelly JW, Palhano FL. Greiner ER, et al. Among authors: kelly jw. PLoS One. 2014 Aug 21;9(8):e105433. doi: 10.1371/journal.pone.0105433. eCollection 2014. PLoS One. 2014. PMID: 25144803 Free PMC article.

9

Targeting protein aggregation for the treatment of degenerative diseases.

Eisele YS, Monteiro C, Fearns C, Encalada SE, Wiseman RL, Powers ET, Kelly JW. Eisele YS, et al. Among authors: kelly jw. Nat Rev Drug Discov. 2015 Nov;14(11):759-80. doi: 10.1038/nrd4593. Epub 2015 Sep 4. Nat Rev Drug Discov. 2015. PMID: 26338154 Free PMC article. Review.

10

A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases.

Baranczak A, Kelly JW. Baranczak A, et al. Among authors: kelly jw. Curr Opin Chem Biol. 2016 Jun;32:10-21. doi: 10.1016/j.cbpa.2016.01.009. Epub 2016 Feb 6. Curr Opin Chem Biol. 2016. PMID: 26859714 Free PMC article. Review.

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