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α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss.
Trudler D, Sanz-Blasco S, Eisele YS, Ghatak S, Bodhinathan K, Akhtar MW, Lynch WP, Piña-Crespo JC, Talantova M, Kelly JW, Lipton SA. Trudler D, et al. Among authors: kelly jw. J Neurosci. 2021 Mar 10;41(10):2264-2273. doi: 10.1523/JNEUROSCI.1871-20.2020. Epub 2021 Jan 22. J Neurosci. 2021. PMID: 33483428 Free PMC article.
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss.
Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Piña-Crespo JC, Lipton SA. Talantova M, et al. Among authors: kelly jw. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2518-27. doi: 10.1073/pnas.1306832110. Epub 2013 Jun 17. Proc Natl Acad Sci U S A. 2013. PMID: 23776240 Free PMC article.
A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans.
Baranczak A, Liu Y, Connelly S, Du WG, Greiner ER, Genereux JC, Wiseman RL, Eisele YS, Bradbury NC, Dong J, Noodleman L, Sharpless KB, Wilson IA, Encalada SE, Kelly JW. Baranczak A, et al. Among authors: kelly jw. J Am Chem Soc. 2015 Jun 17;137(23):7404-14. doi: 10.1021/jacs.5b03042. Epub 2015 Jun 8. J Am Chem Soc. 2015. PMID: 26051248 Free PMC article.
Targeting protein aggregation for the treatment of degenerative diseases.
Eisele YS, Monteiro C, Fearns C, Encalada SE, Wiseman RL, Powers ET, Kelly JW. Eisele YS, et al. Among authors: kelly jw. Nat Rev Drug Discov. 2015 Nov;14(11):759-80. doi: 10.1038/nrd4593. Epub 2015 Sep 4. Nat Rev Drug Discov. 2015. PMID: 26338154 Free PMC article. Review.
Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.
Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW. Schonhoft JD, et al. Among authors: kelly jm, kelly jw. Sci Transl Med. 2017 Sep 13;9(407):eaam7621. doi: 10.1126/scitranslmed.aam7621. Sci Transl Med. 2017. PMID: 28904227 Free PMC article.
Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.
Trudler D, Nazor KL, Eisele YS, Grabauskas T, Dolatabadi N, Parker J, Sultan A, Zhong Z, Goodwin MS, Levites Y, Golde TE, Kelly JW, Sierks MR, Schork NJ, Karin M, Ambasudhan R, Lipton SA. Trudler D, et al. Among authors: kelly jw. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2025847118. doi: 10.1073/pnas.2025847118. Proc Natl Acad Sci U S A. 2021. PMID: 33833060 Free PMC article.
595 results