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MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress.
Nagar S, Noveral SM, Trudler D, Lopez KM, McKercher SR, Han X, Yates JR 3rd, Piña-Crespo JC, Nakanishi N, Satoh T, Okamoto SI, Lipton SA. Nagar S, et al. Among authors: trudler d. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4048-E4056. doi: 10.1073/pnas.1613067114. Epub 2017 May 1. Proc Natl Acad Sci U S A. 2017. PMID: 28461502 Free PMC article.
Novel Direct Conversion of Microglia to Neurons.
Trudler D, Lipton SA. Trudler D, et al. Trends Mol Med. 2019 Feb;25(2):72-74. doi: 10.1016/j.molmed.2018.12.005. Epub 2019 Jan 2. Trends Mol Med. 2019. PMID: 30611669 Free PMC article.
Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.
Trudler D, Nazor KL, Eisele YS, Grabauskas T, Dolatabadi N, Parker J, Sultan A, Zhong Z, Goodwin MS, Levites Y, Golde TE, Kelly JW, Sierks MR, Schork NJ, Karin M, Ambasudhan R, Lipton SA. Trudler D, et al. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2025847118. doi: 10.1073/pnas.2025847118. Proc Natl Acad Sci U S A. 2021. PMID: 33833060 Free PMC article.
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.
Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre JC, Arditi M, Karin M, Sanchez-Lopez E. Xian H, et al. Among authors: trudler d. Immunity. 2021 Jul 13;54(7):1463-1477.e11. doi: 10.1016/j.immuni.2021.05.004. Epub 2021 Jun 10. Immunity. 2021. PMID: 34115964 Free PMC article.
27 results