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A phase 1 trial of the histone deacetylase inhibitor AR-42 in patients with neurofibromatosis type 2-associated tumors and advanced solid malignancies.
Collier KA, Valencia H, Newton H, Hade EM, Sborov DW, Cavaliere R, Poi M, Phelps MA, Liva SG, Coss CC, Wang J, Khountham S, Monk P, Shapiro CL, Piekarz R, Hofmeister CC, Welling DB, Mortazavi A. Collier KA, et al. Among authors: liva sg. Cancer Chemother Pharmacol. 2021 May;87(5):599-611. doi: 10.1007/s00280-020-04229-3. Epub 2021 Jan 25. Cancer Chemother Pharmacol. 2021. PMID: 33492438 Free PMC article. Clinical Trial.
Population Pharmacokinetic Analysis from First-in-Human Data for HDAC Inhibitor, REC-2282 (AR-42), in Patients with Solid Tumors and Hematologic Malignancies: A Case Study for Evaluating Flat vs. Body Size Normalized Dosing.
Liva S, Chen M, Mortazavi A, Walker A, Wang J, Dittmar K, Hofmeister C, Coss CC, Phelps MA. Liva S, et al. Eur J Drug Metab Pharmacokinet. 2021 Nov;46(6):807-816. doi: 10.1007/s13318-021-00722-z. Epub 2021 Oct 7. Eur J Drug Metab Pharmacokinet. 2021. PMID: 34618345 Free PMC article.
Phase I study of AR-42 and decitabine in acute myeloid leukemia.
Liva SG, Coss CC, Wang J, Blum W, Klisovic R, Bhatnagar B, Walsh K, Geyer S, Zhao Q, Garzon R, Marcucci G, Phelps MA, Walker AR. Liva SG, et al. Leuk Lymphoma. 2020 Jun;61(6):1484-1492. doi: 10.1080/10428194.2020.1719095. Epub 2020 Feb 8. Leuk Lymphoma. 2020. PMID: 32037935 Free PMC article. Clinical Trial.
Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans.
Castillo AMM, Vu TT, Liva SG, Chen M, Xie Z, Thomas J, Remaily B, Guo Y, Subrayan UL, Costa T, Helms TH, Irby DJ, Kim K, Owen DH, Kulp SK, Mace TA, Phelps MA, Coss CC. Castillo AMM, et al. Among authors: liva sg. JCSM Rapid Commun. 2021 Jul-Dec;4(2):232-244. doi: 10.1002/rco2.32. Epub 2021 Feb 9. JCSM Rapid Commun. 2021. PMID: 34514376 Free PMC article.
Nipocalimab, an anti-FcRn monoclonal antibody, in participants with moderate to severe active rheumatoid arthritis and inadequate response or intolerance to anti-TNF therapy: results from the phase 2a IRIS-RA study.
Taylor PC, Schett G, Huizinga TW, Wang Q, Ibrahim F, Zhou B, Liva SG, Shaik JSB, Xiong Y, Leu JH, Panchakshari RA, Loza MJ, Ma K, Dhatt H, Rojo Cella R, Karyekar CS, Cuff CA, Gao S, Fei K. Taylor PC, et al. Among authors: liva sg. RMD Open. 2024 Jun 28;10(2):e004278. doi: 10.1136/rmdopen-2024-004278. RMD Open. 2024. PMID: 38942592 Free PMC article. Clinical Trial.