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Page 1
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G; Genomics England Research Consortium; de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. Prentzell MT, et al. Among authors: figlia g. Cell. 2021 Feb 4;184(3):655-674.e27. doi: 10.1016/j.cell.2020.12.024. Epub 2021 Jan 25. Cell. 2021. PMID: 33497611 Free PMC article.
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle.
Carvajal Ibañez D, Skabkin M, Hooli J, Cerrizuela S, Göpferich M, Jolly A, Volk K, Zumwinkel M, Bertolini M, Figlia G, Höfer T, Kramer G, Anders S, Teleman AA, Marciniak-Czochra A, Martin-Villalba A. Carvajal Ibañez D, et al. Among authors: figlia g. EMBO Mol Med. 2023 Apr 11;15(4):e16434. doi: 10.15252/emmm.202216434. Epub 2023 Jan 13. EMBO Mol Med. 2023. PMID: 36636818 Free PMC article.
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor.
Nicastro R, Brohée L, Alba J, Nüchel J, Figlia G, Kipschull S, Gollwitzer P, Romero-Pozuelo J, Fernandes SA, Lamprakis A, Vanni S, Teleman AA, De Virgilio C, Demetriades C. Nicastro R, et al. Among authors: figlia g. Nat Cell Biol. 2023 Sep;25(9):1303-1318. doi: 10.1038/s41556-023-01198-6. Epub 2023 Aug 10. Nat Cell Biol. 2023. PMID: 37563253 Free PMC article.
Myelination and mTOR.
Figlia G, Gerber D, Suter U. Figlia G, et al. Glia. 2018 Apr;66(4):693-707. doi: 10.1002/glia.23273. Epub 2017 Dec 6. Glia. 2018. PMID: 29210103 Free PMC article. Review.
18 results