Pusch S - Search Results

1

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.

Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G; Genomics England Research Consortium; de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. Prentzell MT, et al. Among authors: pusch s. Cell. 2021 Feb 4;184(3):655-674.e27. doi: 10.1016/j.cell.2020.12.024. Epub 2021 Jan 25. Cell. 2021. PMID: 33497611 Free PMC article.

2

PCR- and restriction endonuclease-based detection of IDH1 mutations.

Meyer J, Pusch S, Balss J, Capper D, Mueller W, Christians A, Hartmann C, von Deimling A. Meyer J, et al. Among authors: pusch s. Brain Pathol. 2010 Mar;20(2):298-300. doi: 10.1111/j.1750-3639.2009.00327.x. Epub 2009 Aug 18. Brain Pathol. 2010. PMID: 19744125 Free PMC article.

3

D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma.

Pusch S, Schweizer L, Beck AC, Lehmler JM, Weissert S, Balss J, Miller AK, von Deimling A. Pusch S, et al. Acta Neuropathol Commun. 2014 Feb 14;2:19. doi: 10.1186/2051-5960-2-19. Acta Neuropathol Commun. 2014. PMID: 24529257 Free PMC article.

4

Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway.

Ott M, Litzenburger UM, Rauschenbach KJ, Bunse L, Ochs K, Sahm F, Pusch S, Opitz CA, Blaes J, von Deimling A, Wick W, Platten M. Ott M, et al. Among authors: pusch s. Glia. 2015 Jan;63(1):78-90. doi: 10.1002/glia.22734. Epub 2014 Aug 5. Glia. 2015. PMID: 25132599

5

Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1.

Ma T, Zou F, Pusch S, Yang L, Zhu Q, Xu Y, Gu Y, von Deimling A, Zha X. Ma T, et al. Among authors: pusch s. Bioorg Med Chem. 2017 Dec 15;25(24):6379-6387. doi: 10.1016/j.bmc.2017.10.009. Epub 2017 Oct 13. Bioorg Med Chem. 2017. PMID: 29089260

6

Identification of novel allosteric inhibitors of mutant isocitrate dehydrogenase 1 by cross docking-based virtual screening.

Zou F, Pusch S, Hua J, Ma T, Yang L, Zhu Q, Xu Y, Gu Y, von Deimling A, Zha X. Zou F, et al. Among authors: pusch s. Bioorg Med Chem Lett. 2018 Feb 1;28(3):388-393. doi: 10.1016/j.bmcl.2017.12.030. Epub 2017 Dec 13. Bioorg Med Chem Lett. 2018. PMID: 29290542

7

Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): An Update and Perspective.

Ma T, Zou F, Pusch S, Xu Y, von Deimling A, Zha X. Ma T, et al. Among authors: pusch s. J Med Chem. 2018 Oct 25;61(20):8981-9003. doi: 10.1021/acs.jmedchem.8b00159. Epub 2018 Jun 18. J Med Chem. 2018. PMID: 29847930 Review.

8

Characterization of the epithelial membrane protein 3 interaction network reveals a potential functional link to mitogenic signal transduction regulation.

Christians A, Poisel E, Hartmann C, von Deimling A, Pusch S. Christians A, et al. Among authors: pusch s. Int J Cancer. 2019 Jul 15;145(2):461-473. doi: 10.1002/ijc.32107. Epub 2019 Jan 20. Int J Cancer. 2019. PMID: 30614533

9

mIDH-associated DNA hypermethylation in acute myeloid leukemia reflects differentiation blockage rather than inhibition of TET-mediated demethylation.

Wiehle L, Raddatz G, Pusch S, Gutekunst J, von Deimling A, Rodríguez-Paredes M, Lyko F. Wiehle L, et al. Among authors: pusch s. Cell Stress. 2017 Sep 20;1(1):55-67. doi: 10.15698/cst2017.10.106. Cell Stress. 2017. PMID: 31225434 Free PMC article.

10

EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma.

Martija AA, Krauß A, Bächle N, Doth L, Christians A, Krunic D, Schneider M, Helm D, Will R, Hartmann C, Herold-Mende C, von Deimling A, Pusch S. Martija AA, et al. Among authors: pusch s. Acta Neuropathol Commun. 2023 Nov 7;11(1):177. doi: 10.1186/s40478-023-01673-z. Acta Neuropathol Commun. 2023. PMID: 37936247 Free PMC article.

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