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Page 1
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.
Okatsu K, Oka T, Iguchi M, Imamura K, Kosako H, Tani N, Kimura M, Go E, Koyano F, Funayama M, Shiba-Fukushima K, Sato S, Shimizu H, Fukunaga Y, Taniguchi H, Komatsu M, Hattori N, Mihara K, Tanaka K, Matsuda N. Okatsu K, et al. Among authors: kosako h. Nat Commun. 2012;3:1016. doi: 10.1038/ncomms2016. Nat Commun. 2012. PMID: 22910362 Free PMC article.
Ubiquitin is phosphorylated by PINK1 to activate parkin.
Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, Kimura Y, Tsuchiya H, Yoshihara H, Hirokawa T, Endo T, Fon EA, Trempe JF, Saeki Y, Tanaka K, Matsuda N. Koyano F, et al. Among authors: kosako h. Nature. 2014 Jun 5;510(7503):162-6. doi: 10.1038/nature13392. Epub 2014 Jun 4. Nature. 2014. PMID: 24784582
Phosphorylated ubiquitin chain is the genuine Parkin receptor.
Okatsu K, Koyano F, Kimura M, Kosako H, Saeki Y, Tanaka K, Matsuda N. Okatsu K, et al. Among authors: kosako h. J Cell Biol. 2015 Apr 13;209(1):111-28. doi: 10.1083/jcb.201410050. Epub 2015 Apr 6. J Cell Biol. 2015. PMID: 25847540 Free PMC article.
Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.
Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin AC, Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako H, Takahama Y. Ohigashi I, et al. Among authors: kosako h. Cell Rep. 2019 Nov 26;29(9):2901-2916.e6. doi: 10.1016/j.celrep.2019.10.079. Cell Rep. 2019. PMID: 31775054 Free PMC article.
HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence.
Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S. Cui M, et al. Among authors: kosako h. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2306454120. doi: 10.1073/pnas.2306454120. Epub 2024 Jan 3. Proc Natl Acad Sci U S A. 2024. PMID: 38170752 Free PMC article.
132 results