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Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.
Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GH, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, Tansey WP, Verba KA, Vos SM, Weiss WA, Wolf E, Mossé YP. Wolpaw AJ, et al. Among authors: gustafson wc. Cancer Res. 2021 Apr 1;81(7):1627-1632. doi: 10.1158/0008-5472.CAN-20-3108. Epub 2021 Jan 28. Cancer Res. 2021. PMID: 33509943 Free PMC article. Review.
Myc proteins as therapeutic targets.
Gustafson WC, Weiss WA. Gustafson WC, et al. Oncogene. 2010 Mar 4;29(9):1249-59. doi: 10.1038/onc.2009.512. Epub 2010 Jan 25. Oncogene. 2010. PMID: 20101214 Free PMC article.
Addiction to B-MYB.
Gustafson WC, Weiss WA. Gustafson WC, et al. Oncotarget. 2010 Aug;1(4):235-236. doi: 10.18632/oncotarget.132. Oncotarget. 2010. PMID: 21304174 Free PMC article. No abstract available.
Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model.
Seo Y, Gustafson WC, Dannoon SF, Nekritz EA, Lee CL, Murphy ST, VanBrocklin HF, Hernandez-Pampaloni M, Haas-Kogan DA, Weiss WA, Matthay KK. Seo Y, et al. Among authors: gustafson wc. Mol Imaging Biol. 2012 Dec;14(6):735-42. doi: 10.1007/s11307-012-0552-4. Mol Imaging Biol. 2012. PMID: 22382618 Free PMC article.
Targeting MYCN in neuroblastoma by BET bromodomain inhibition.
Puissant A, Frumm SM, Alexe G, Bassil CF, Qi J, Chanthery YH, Nekritz EA, Zeid R, Gustafson WC, Greninger P, Garnett MJ, McDermott U, Benes CH, Kung AL, Weiss WA, Bradner JE, Stegmaier K. Puissant A, et al. Among authors: gustafson wc. Cancer Discov. 2013 Mar;3(3):308-23. doi: 10.1158/2159-8290.CD-12-0418. Epub 2013 Feb 21. Cancer Discov. 2013. PMID: 23430699 Free PMC article.
Drugging MYCN through an allosteric transition in Aurora kinase A.
Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA. Gustafson WC, et al. Cancer Cell. 2014 Sep 8;26(3):414-427. doi: 10.1016/j.ccr.2014.07.015. Epub 2014 Aug 28. Cancer Cell. 2014. PMID: 25175806 Free PMC article.
41 results