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Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.
Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GH, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, Tansey WP, Verba KA, Vos SM, Weiss WA, Wolf E, Mossé YP. Wolpaw AJ, et al. Among authors: tansey wp. Cancer Res. 2021 Apr 1;81(7):1627-1632. doi: 10.1158/0008-5472.CAN-20-3108. Epub 2021 Jan 28. Cancer Res. 2021. PMID: 33509943 Free PMC article. Review.
The MYC-WDR5 Nexus and Cancer.
Thomas LR, Foshage AM, Weissmiller AM, Tansey WP. Thomas LR, et al. Among authors: tansey wp. Cancer Res. 2015 Oct 1;75(19):4012-5. doi: 10.1158/0008-5472.CAN-15-1216. Epub 2015 Sep 17. Cancer Res. 2015. PMID: 26383167 Free PMC article. Review.
Adenoviral E1A function through Myc.
Chakraborty AA, Tansey WP. Chakraborty AA, et al. Among authors: tansey wp. Cancer Res. 2009 Jan 1;69(1):6-9. doi: 10.1158/0008-5472.CAN-08-3026. Cancer Res. 2009. PMID: 19117980 Review.
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
Macdonald JD, Chacón Simon S, Han C, Wang F, Shaw JG, Howes JE, Sai J, Yuh JP, Camper D, Alicie BM, Alvarado J, Nikhar S, Payne W, Aho ER, Bauer JA, Zhao B, Phan J, Thomas LR, Rossanese OW, Tansey WP, Waterson AG, Stauffer SR, Fesik SW. Macdonald JD, et al. Among authors: tansey wp. J Med Chem. 2019 Dec 26;62(24):11232-11259. doi: 10.1021/acs.jmedchem.9b01411. Epub 2019 Dec 5. J Med Chem. 2019. PMID: 31724864 Free PMC article.
Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design.
Chacón Simon S, Wang F, Thomas LR, Phan J, Zhao B, Olejniczak ET, Macdonald JD, Shaw JG, Schlund C, Payne W, Creighton J, Stauffer SR, Waterson AG, Tansey WP, Fesik SW. Chacón Simon S, et al. Among authors: tansey wp. J Med Chem. 2020 Apr 23;63(8):4315-4333. doi: 10.1021/acs.jmedchem.0c00224. Epub 2020 Apr 9. J Med Chem. 2020. PMID: 32223236 Free PMC article.
107 results