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92 results

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Page 1
Stereochemistry Enhances Potency, Efficacy, and Durability of Malat1 Antisense Oligonucleotides In Vitro and In Vivo in Multiple Species.
Byrne M, Vathipadiekal V, Apponi L, Iwamoto N, Kandasamy P, Longo K, Liu F, Looby R, Norwood L, Shah A, Shelke JD, Shivalila C, Yang H, Yin Y, Guo L, Bowman K, Vargeese C. Byrne M, et al. Among authors: kandasamy p. Transl Vis Sci Technol. 2021 Jan 12;10(1):23. doi: 10.1167/tvst.10.1.23. eCollection 2021 Jan. Transl Vis Sci Technol. 2021. PMID: 33510962 Free PMC article.
Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models.
Liu Y, Dodart JC, Tran H, Berkovitch S, Braun M, Byrne M, Durbin AF, Hu XS, Iwamoto N, Jang HG, Kandasamy P, Liu F, Longo K, Ruschel J, Shelke J, Yang H, Yin Y, Donner A, Zhong Z, Vargeese C, Brown RH Jr. Liu Y, et al. Among authors: kandasamy p. Nat Commun. 2021 Feb 8;12(1):847. doi: 10.1038/s41467-021-21112-8. Nat Commun. 2021. PMID: 33558503 Free PMC article.
Quantitative Measurement of Cytosolic and Nuclear Penetration of Oligonucleotide Therapeutics.
Deprey K, Batistatou N, Debets MF, Godfrey J, VanderWall KB, Miles RR, Shehaj L, Guo J, Andreucci A, Kandasamy P, Lu G, Shimizu M, Vargeese C, Kritzer JA. Deprey K, et al. Among authors: kandasamy p. ACS Chem Biol. 2022 Feb 18;17(2):348-360. doi: 10.1021/acschembio.1c00830. Epub 2022 Jan 15. ACS Chem Biol. 2022. PMID: 35034446 Free PMC article.
Control of backbone chemistry and chirality boost oligonucleotide splice switching activity.
Kandasamy P, McClorey G, Shimizu M, Kothari N, Alam R, Iwamoto N, Kumarasamy J, Bommineni GR, Bezigian A, Chivatakarn O, Butler DCD, Byrne M, Chwalenia K, Davies KE, Desai J, Shelke JD, Durbin AF, Ellerington R, Edwards B, Godfrey J, Hoss A, Liu F, Longo K, Lu G, Marappan S, Oieni J, Paik IH, Estabrook EP, Shivalila C, Tischbein M, Kawamoto T, Rinaldi C, Rajão-Saraiva J, Tripathi S, Yang H, Yin Y, Zhao X, Zhou C, Zhang J, Apponi L, Wood MJA, Vargeese C. Kandasamy P, et al. Nucleic Acids Res. 2022 Jun 10;50(10):5443-5466. doi: 10.1093/nar/gkac018. Nucleic Acids Res. 2022. PMID: 35061895 Free PMC article.
Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS.
Kandasamy P, Liu Y, Aduda V, Akare S, Alam R, Andreucci A, Boulay D, Bowman K, Byrne M, Cannon M, Chivatakarn O, Shelke JD, Iwamoto N, Kawamoto T, Kumarasamy J, Lamore S, Lemaitre M, Lin X, Longo K, Looby R, Marappan S, Metterville J, Mohapatra S, Newman B, Paik IH, Patil S, Purcell-Estabrook E, Shimizu M, Shum P, Standley S, Taborn K, Tripathi S, Yang H, Yin Y, Zhao X, Dale E, Vargeese C. Kandasamy P, et al. Nucleic Acids Res. 2022 Jun 10;50(10):5401-5423. doi: 10.1093/nar/gkac037. Nucleic Acids Res. 2022. PMID: 35106589 Free PMC article.
Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides.
Monian P, Shivalila C, Lu G, Shimizu M, Boulay D, Bussow K, Byrne M, Bezigian A, Chatterjee A, Chew D, Desai J, Favaloro F, Godfrey J, Hoss A, Iwamoto N, Kawamoto T, Kumarasamy J, Lamattina A, Lindsey A, Liu F, Looby R, Marappan S, Metterville J, Murphy R, Rossi J, Pu T, Bhattarai B, Standley S, Tripathi S, Yang H, Yin Y, Yu H, Zhou C, Apponi LH, Kandasamy P, Vargeese C. Monian P, et al. Among authors: kandasamy p. Nat Biotechnol. 2022 Jul;40(7):1093-1102. doi: 10.1038/s41587-022-01225-1. Epub 2022 Mar 7. Nat Biotechnol. 2022. PMID: 35256816
Impact of stereopure chimeric backbone chemistries on the potency and durability of gene silencing by RNA interference.
Liu W, Iwamoto N, Marappan S, Luu K, Tripathi S, Purcell-Estabrook E, Shelke JD, Shah H, Lamattina A, Pan Q, Schrand B, Favaloro F, Bedekar M, Chatterjee A, Desai J, Kawamoto T, Lu G, Metterville J, Samaraweera M, Prakasha PS, Yang H, Yin Y, Yu H, Giangrande PH, Byrne M, Kandasamy P, Vargeese C. Liu W, et al. Among authors: kandasamy p. Nucleic Acids Res. 2023 May 22;51(9):4126-4147. doi: 10.1093/nar/gkad268. Nucleic Acids Res. 2023. PMID: 37070173 Free PMC article.
Preclinical evaluation of stereopure antisense oligonucleotides for allele-selective lowering of mutant HTT.
Iwamoto N, Liu Y, Frank-Kamenetsky M, Maguire A, Tseng WC, Taborn K, Kothari N, Akhtar A, Bowman K, Shelke JD, Lamattina A, Hu XS, Jang HG, Kandasamy P, Liu F, Longo K, Looby R, Meena, Metterville J, Pan Q, Purcell-Estabrook E, Shimizu M, Prakasha PS, Standley S, Upadhyay H, Yang H, Yin Y, Zhao A, Francis C, Byrne M, Dale E, Verdine GL, Vargeese C. Iwamoto N, et al. Among authors: kandasamy p. Mol Ther Nucleic Acids. 2024 Jun 11;35(3):102246. doi: 10.1016/j.omtn.2024.102246. eCollection 2024 Sep 10. Mol Ther Nucleic Acids. 2024. PMID: 39027419 Free PMC article.
Rational design of base, sugar and backbone modifications improves ADAR-mediated RNA editing.
Lu G, Shivalila C, Monian P, Yu H, Harding I, Briem S, Byrne M, Faraone A, Friend S, Huth O, Iwamoto N, Kawamoto T, Kumarasamy J, Lamattina A, Longo K, McCarthy L, McGlynn A, Molski A, Pan Q, Pu T, Purcell-Estabrook E, Rossi J, Standley S, Thomas C, Walen A, Yang H, Kandasamy P, Vargeese C. Lu G, et al. Among authors: kandasamy p. Nucleic Acids Res. 2024 Sep 23;52(17):10068-10084. doi: 10.1093/nar/gkae681. Nucleic Acids Res. 2024. PMID: 39149897 Free PMC article.
Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.
Nair JK, Willoughby JL, Chan A, Charisse K, Alam MR, Wang Q, Hoekstra M, Kandasamy P, Kel'in AV, Milstein S, Taneja N, O'Shea J, Shaikh S, Zhang L, van der Sluis RJ, Jung ME, Akinc A, Hutabarat R, Kuchimanchi S, Fitzgerald K, Zimmermann T, van Berkel TJ, Maier MA, Rajeev KG, Manoharan M. Nair JK, et al. Among authors: kandasamy p. J Am Chem Soc. 2014 Dec 10;136(49):16958-61. doi: 10.1021/ja505986a. Epub 2014 Dec 1. J Am Chem Soc. 2014. PMID: 25434769
92 results