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Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis.
Toledo MAS, Gatz M, Sontag S, Gleixner KV, Eisenwort G, Feldberg K, Hamouda AEI, Kluge F, Guareschi R, Rossetti G, Sechi AS, Dufva OMJ, Mustjoki SM, Maurer A, Schüler HM, Goetzke R, Braunschweig T, Kaiser A, Panse J, Jawhar M, Reiter A, Hilberg F, Ettmayer P, Wagner W, Koschmieder S, Brümmendorf TH, Valent P, Chatain N, Zenke M. Toledo MAS, et al. Among authors: rossetti g. Blood. 2021 Apr 15;137(15):2070-2084. doi: 10.1182/blood.2019004509. Blood. 2021. PMID: 33512435 Free article.
A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action.
Campaner E, Rustighi A, Zannini A, Cristiani A, Piazza S, Ciani Y, Kalid O, Golan G, Baloglu E, Shacham S, Valsasina B, Cucchi U, Pippione AC, Lolli ML, Giabbai B, Storici P, Carloni P, Rossetti G, Benvenuti F, Bello E, D'Incalci M, Cappuzzello E, Rosato A, Del Sal G. Campaner E, et al. Among authors: rossetti g. Nat Commun. 2017 Jun 9;8:15772. doi: 10.1038/ncomms15772. Nat Commun. 2017. PMID: 28598431 Free PMC article.
Sulfoximines as ATR inhibitors: Analogs of VE-821.
Hendriks CMM, Hartkamp J, Wiezorek S, Steinkamp AD, Rossetti G, Lüscher B, Bolm C. Hendriks CMM, et al. Among authors: rossetti g. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2659-2662. doi: 10.1016/j.bmcl.2017.04.026. Epub 2017 Apr 8. Bioorg Med Chem Lett. 2017. PMID: 28479198
KIRA6 is an Effective and Versatile Mast Cell Inhibitor of IgE-mediated Activation.
Wunderle V, Wilhelm T, Boukeileh S, Goßen J, Margreiter MA, Sakurov R, Capellmann S, Schwoerer M, Ahmed N, Bronneberg G, Arock M, Martin C, Schubert T, Levi-Schaffer F, Rossetti G, Tirosh B, Huber M. Wunderle V, et al. Among authors: rossetti g. Eur J Immunol. 2024 Dec 15:e202451348. doi: 10.1002/eji.202451348. Online ahead of print. Eur J Immunol. 2024. PMID: 39676406
378 results