Spiegel PC - Search Results

1

Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor.

Gish JS, Jarvis L, Childers KC, Peters SC, Garrels CS, Smith IW, Spencer HT, Doering CB, Lollar P, Spiegel PC. Gish JS, et al. Among authors: spiegel pc. Blood. 2021 May 27;137(21):2981-2986. doi: 10.1182/blood.2020008940. Blood. 2021. PMID: 33529335 Free PMC article.

2

Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII.

Spiegel PC Jr, Jacquemin M, Saint-Remy JM, Stoddard BL, Pratt KP. Spiegel PC Jr, et al. Blood. 2001 Jul 1;98(1):13-9. doi: 10.1182/blood.v98.1.13. Blood. 2001. PMID: 11418455 Free article.

3

The tertiary structure and domain organization of coagulation factor VIII.

Shen BW, Spiegel PC, Chang CH, Huh JW, Lee JS, Kim J, Kim YH, Stoddard BL. Shen BW, et al. Among authors: spiegel pc. Blood. 2008 Feb 1;111(3):1240-7. doi: 10.1182/blood-2007-08-109918. Epub 2007 Oct 26. Blood. 2008. PMID: 17965321 Free PMC article.

4

Characterization and solution structure of the factor VIII C2 domain in a ternary complex with classical and non-classical inhibitor antibodies.

Walter JD, Werther RA, Polozova MS, Pohlman J, Healey JF, Meeks SL, Lollar P, Spiegel PC Jr. Walter JD, et al. Among authors: spiegel pc jr. J Biol Chem. 2013 Apr 5;288(14):9905-9914. doi: 10.1074/jbc.M112.424564. Epub 2013 Feb 15. J Biol Chem. 2013. PMID: 23417672 Free PMC article.

5

Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes.

Walter JD, Werther RA, Brison CM, Cragerud RK, Healey JF, Meeks SL, Lollar P, Spiegel PC Jr. Walter JD, et al. Among authors: spiegel pc jr. Blood. 2013 Dec 19;122(26):4270-8. doi: 10.1182/blood-2013-08-519124. Epub 2013 Oct 1. Blood. 2013. PMID: 24085769 Free PMC article.

6

The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfaces.

Brison CM, Mullen SM, Wuerth ME, Podolsky K, Cook M, Herman JA, Walter JD, Meeks SL, Spiegel PC. Brison CM, et al. Among authors: spiegel pc. PLoS One. 2015 Mar 16;10(3):e0122447. doi: 10.1371/journal.pone.0122447. eCollection 2015. PLoS One. 2015. PMID: 25775247 Free PMC article.

7

Structure of the Human Factor VIII C2 Domain in Complex with the 3E6 Inhibitory Antibody.

Wuerth ME, Cragerud RK, Spiegel PC. Wuerth ME, et al. Among authors: spiegel pc. Sci Rep. 2015 Nov 24;5:17216. doi: 10.1038/srep17216. Sci Rep. 2015. PMID: 26598467 Free PMC article.

8

The 3.2 Å structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain.

Smith IW, d'Aquino AE, Coyle CW, Fedanov A, Parker ET, Denning G, Spencer HT, Lollar P, Doering CB, Spiegel PC Jr. Smith IW, et al. Among authors: spiegel pc jr. J Thromb Haemost. 2020 Jan;18(1):57-69. doi: 10.1111/jth.14621. Epub 2019 Sep 8. J Thromb Haemost. 2020. PMID: 31454152 Free PMC article.

9

Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor.

Ronayne EK, Peters SC, Gish JS, Wilson C, Spencer HT, Doering CB, Lollar P, Spiegel PC Jr, Childers KC. Ronayne EK, et al. Among authors: spiegel pc jr. Front Immunol. 2021 Jun 10;12:697602. doi: 10.3389/fimmu.2021.697602. eCollection 2021. Front Immunol. 2021. PMID: 34177966 Free PMC article.

10

VWF self-association requires tensile force.

Spiegel PC. Spiegel PC. Blood. 2021 Dec 9;138(23):2309-2310. doi: 10.1182/blood.2021013534. Blood. 2021. PMID: 34882209 Free article. No abstract available.

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