Xu Y - Search Results

1

Discovery of novel diarylamides as orally active diuretics targeting urea transporters.

Zhang S, Zhao Y, Wang S, Li M, Xu Y, Ran J, Geng X, He J, Meng J, Shao G, Zhou H, Ge Z, Chen G, Li R, Yang B. Zhang S, et al. Among authors: xu y. Acta Pharm Sin B. 2021 Jan;11(1):181-202. doi: 10.1016/j.apsb.2020.06.001. Epub 2020 Jun 14. Acta Pharm Sin B. 2021. PMID: 33532188 Free PMC article.

2

A thienopyridine, CB-20, exerts diuretic activity by inhibiting urea transporters.

Li M, Zhao Y, Zhang S, Xu Y, Wang SY, Li BW, Ran JH, Li RT, Yang BX. Li M, et al. Among authors: xu y. Acta Pharmacol Sin. 2020 Jan;41(1):65-72. doi: 10.1038/s41401-019-0245-5. Epub 2019 Jun 18. Acta Pharmacol Sin. 2020. PMID: 31213671 Free PMC article.

3

Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor.

Abulizi A, Hu L, Ma A, Shao FY, Zhu HZ, Lin SM, Shao GY, Xu Y, Ran JH, Li J, Zhou H, Lin DM, Wang LF, Li M, Yang BX. Abulizi A, et al. Among authors: xu y. Acta Pharmacol Sin. 2021 Oct;42(10):1703-1713. doi: 10.1038/s41401-021-00669-6. Epub 2021 Apr 29. Acta Pharmacol Sin. 2021. PMID: 33927358 Free PMC article.

4

Inhibiting Focal Adhesion Kinase Ameliorates Cyst Development in Polycystin-1-Deficient Polycystic Kidney Disease in Animal Model.

He J, Zhang S, Qiu Z, Li X, Huang H, Jin W, Xu Y, Shao G, Wang L, Meng J, Wang S, Geng X, Jia Y, Li M, Yang B, Jenny Lu HA, Zhou H. He J, et al. Among authors: xu y. J Am Soc Nephrol. 2021 Sep;32(9):2159-2174. doi: 10.1681/ASN.2020111560. J Am Soc Nephrol. 2021. PMID: 34465607 Free PMC article.

5

N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide as a novel orally available diuretic that targets urea transporters with improved PD and PK properties.

Wang S, Xu Y, Zhao Y, Zhang S, Li M, Li X, He J, Zhou H, Ge Z, Li R, Yang B. Wang S, et al. Among authors: xu y. Eur J Med Chem. 2021 Dec 15;226:113859. doi: 10.1016/j.ejmech.2021.113859. Epub 2021 Sep 24. Eur J Med Chem. 2021. PMID: 34601246

6

Preclinical Pharmacokinetic Studies of a Novel Diuretic Inhibiting Urea Transporters.

Xu Y, Zhang H, Li N, Ma W, Wang S, Sun J, Yang B. Xu Y, et al. Molecules. 2022 Apr 11;27(8):2451. doi: 10.3390/molecules27082451. Molecules. 2022. PMID: 35458649 Free PMC article.

7

An HPLC-MS/MS Method for Pharmacokinetic Study of Y-99: A Novel Diuretic Agent Targeting Urea Transporters.

Xu Y, Wang S, Ma W, Li J, Lu Y, Abulizi A, Sun J, Yang B. Xu Y, et al. J Chromatogr Sci. 2023 Jul 9;61(6):552-558. doi: 10.1093/chromsci/bmac089. J Chromatogr Sci. 2023. PMID: 36369644

8

Urea transporter UT-A1 as a novel drug target for hyponatremia.

Li N, Zhang H, Wang S, Xu Y, Ying Y, Li J, Li X, Li M, Yang B. Li N, et al. Among authors: xu y. FASEB J. 2024 Jul 15;38(13):e23760. doi: 10.1096/fj.202400555RR. FASEB J. 2024. PMID: 38924449

9

Ganoderma lucidum Polysaccharide Peptide Alleviates Cyclophosphamide-Induced Male Reproductive Injury by Reducing Oxidative Stress and Apoptosis.

Zhang H, Li N, Zhang Y, Xu Y, Lu F, Lin D, Lin S, Li M, Yang B. Zhang H, et al. Among authors: xu y. Biomedicines. 2024 Jul 23;12(8):1632. doi: 10.3390/biomedicines12081632. Biomedicines. 2024. PMID: 39200097 Free PMC article.

10

Discovery of 3-oxo-1,2,3,4-tetrahydropyrido[1,2-a]pyrazin derivatives as SARS-CoV-2 main protease inhibitors through virtual screening and biological evaluation.

Dou X, Sun Q, Liu Y, Lu Y, Zhang C, Xu G, Xu Y, Huo T, Zhao X, Su L, Xing Y, Lai L, Jiao N. Dou X, et al. Among authors: xu g, xu y. Bioorg Med Chem Lett. 2024 Jan 1;97:129547. doi: 10.1016/j.bmcl.2023.129547. Epub 2023 Nov 8. Bioorg Med Chem Lett. 2024. PMID: 37944867

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