Cai H - Search Results

1

Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer.

Lo AA, Johnston J, Li J, Mandikian D, Hristopoulos M, Clark R, Nickles D, Liang WC, Hötzel K, Dunlap D, Pham T, Cai H, Ovacik M, Bravo-Perez D, Mai E, Slaga D, Ellerman D, Ziai J, Totpal K, Lee G, Boswell CA, Payandeh J, Wu Y, Junttila TT. Lo AA, et al. Among authors: cai h. Mol Cancer Ther. 2021 Apr;20(4):716-725. doi: 10.1158/1535-7163.MCT-20-0490. Epub 2021 Feb 3. Mol Cancer Ther. 2021. PMID: 33536191

2

Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies.

Hsiao YC, Shang Y, DiCara DM, Yee A, Lai J, Kim SH, Ellerman D, Corpuz R, Chen Y, Rajan S, Cai H, Wu Y, Seshasayee D, Hötzel I. Hsiao YC, et al. Among authors: cai h. MAbs. 2019 May/Jun;11(4):735-746. doi: 10.1080/19420862.2019.1584517. Epub 2019 Mar 22. MAbs. 2019. PMID: 30900945 Free PMC article.

3

Balancing the Affinity and Pharmacokinetics of Antibodies by Modulating the Size of Charge Patches on Complementarity-Determining Regions.

Sun Y, Cai H, Hu Z, Boswell CA, Diao J, Li C, Zhang L, Shen A, Teske CA, Zhang B, Kamath AV, Jiang G. Sun Y, et al. Among authors: cai h. J Pharm Sci. 2020 Dec;109(12):3690-3696. doi: 10.1016/j.xphs.2020.09.003. Epub 2020 Sep 7. J Pharm Sci. 2020. PMID: 32910947

4

A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma.

Kakiuchi-Kiyota S, Ross T, Wallweber HA, Kiefer JR, Schutten MM, Adedeji AO, Cai H, Hendricks R, Cohen S, Myneni S, Liu L, Fullerton A, Corr N, Yu L, de Almeida Nagata D, Zhong S, Leong SR, Li J, Nakamura R, Sumiyoshi T, Li J, Ovacik AM, Zheng B, Dillon M, Spiess C, Wingert S, Rajkovic E, Ellwanger K, Reusch U, Polson AG. Kakiuchi-Kiyota S, et al. Among authors: cai h. Leukemia. 2022 Apr;36(4):1006-1014. doi: 10.1038/s41375-021-01478-w. Epub 2022 Jan 10. Leukemia. 2022. PMID: 35001074

5

Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple Myeloma.

Cai H, Kakiuchi-Kiyota S, Hendricks R, Zhong S, Liu L, Adedeji AO, Chan P, Schutten MM, Kamath AV, Ovacik MA. Cai H, et al. AAPS J. 2022 Sep 20;24(6):100. doi: 10.1208/s12248-022-00744-8. AAPS J. 2022. PMID: 36127472

6

Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti-Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats.

Cai H, Yip V, Lee MV, Wong S, Saad O, Ma S, Ljumanovic N, Khojasteh SC, Kamath AV, Shen BQ. Cai H, et al. Drug Metab Dispos. 2020 Nov;48(11):1161-1168. doi: 10.1124/dmd.120.000092. Epub 2020 Aug 24. Drug Metab Dispos. 2020. PMID: 32839277

7

Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid.

Sadekar SS, Bowen M, Cai H, Jamalian S, Rafidi H, Shatz-Binder W, Lafrance-Vanasse J, Chan P, Meilandt WJ, Oldendorp A, Sreedhara A, Daugherty A, Crowell S, Wildsmith KR, Atwal J, Fuji RN, Horvath J. Sadekar SS, et al. Among authors: cai h. Clin Pharmacol Ther. 2022 Apr;111(4):826-834. doi: 10.1002/cpt.2531. Epub 2022 Feb 23. Clin Pharmacol Ther. 2022. PMID: 35064573 Free PMC article. Review.

8

Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus.

Deng R, Zhou C, Li D, Cai H, Sukumaran S, Carrasco-Triguero M, Saad O, Nazzal D, Lowe C, Ramanujan S, Kamath AV. Deng R, et al. Among authors: cai h. MAbs. 2019 Aug/Sep;11(6):1162-1174. doi: 10.1080/19420862.2019.1627152. Epub 2019 Jun 20. MAbs. 2019. PMID: 31219754 Free PMC article.

9

Nonclinical toxicology development of a novel antibody antibiotic conjugate for treating invasive Staphylococcus Aureus infections.

Stagg NJ, Katavolos P, Achilles Poon K, Zhong S, Ljumanovic N, Kamath A, Cai H, Carrasco-Triguero M, Halpern W. Stagg NJ, et al. Among authors: cai h. Toxicol Appl Pharmacol. 2022 Jan 15;435:115811. doi: 10.1016/j.taap.2021.115811. Epub 2021 Dec 9. Toxicol Appl Pharmacol. 2022. PMID: 34896194

10

Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis.

Chavarria-Smith J, Chiu CPC, Jackman JK, Yin J, Zhang J, Hackney JA, Lin WY, Tyagi T, Sun Y, Tao J, Dunlap D, Morton WD, Ghodge SV, Maun HR, Li H, Hernandez-Barry H, Loyet KM, Chen E, Liu J, Tam C, Yaspan BL, Cai H, Balazs M, Arron JR, Li J, Wittwer AJ, Pappu R, Austin CD, Lee WP, Lazarus RA, Sudhamsu J, Koerber JT, Yi T. Chavarria-Smith J, et al. Among authors: cai h. Sci Transl Med. 2022 Dec 14;14(675):eabp9159. doi: 10.1126/scitranslmed.abp9159. Epub 2022 Dec 14. Sci Transl Med. 2022. PMID: 36516271

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