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Mutant prevention concentrations, in vitro resistance evolution dynamics, and mechanisms of resistance to imipenem and imipenem/relebactam in carbapenem-susceptible Klebsiella pneumoniae isolates showing ceftazidime/avibactam resistance.
Blanco-Martín T, González-Pinto L, Aja-Macaya P, Rodríguez-Pallares S, Sánchez-Peña L, Gato E, Fernández-López MdC, Outeda-García M, Rodríguez-Coello A, Pedraza-Merino R, Alonso-García I, Vázquez-Ucha JC, Martínez-Martínez L, Arca-Suárez J, Beceiro A, Bou G. Blanco-Martín T, et al. Among authors: gato e. Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0112024. doi: 10.1128/aac.01120-24. Epub 2024 Nov 15. Antimicrob Agents Chemother. 2024. PMID: 39545736 Free PMC article.
In vitro development of imipenem/relebactam resistance in KPC-producing Klebsiella pneumoniae involves multiple mutations including OmpK36 disruption and KPC modification.
Gato E, Guijarro-Sánchez P, Alonso-García I, Pedraza-Merino R, Conde A, Lence E, Rumbo-Feal S, Peña-Escolano A, Lasarte-Monterrubio C, Blanco-Martín T, Fernández-González A, Fernández-López MDC, Maceiras R, Martínez-Guitián M, Vázquez-Ucha JC, Martínez-Martínez L, González-Bello C, Arca-Suárez J, Beceiro A, Bou G. Gato E, et al. Int J Antimicrob Agents. 2023 Oct;62(4):106935. doi: 10.1016/j.ijantimicag.2023.106935. Epub 2023 Aug 3. Int J Antimicrob Agents. 2023. PMID: 37541530
Multicenter Performance Evaluation of MALDI-TOF MS for Rapid Detection of Carbapenemase Activity in Enterobacterales: The Future of Networking Data Analysis With Online Software.
Gato E, Anantharajah A, Arroyo MJ, Artacho MJ, Caballero JD, Candela A, Chudějová K, Constanso IP, Elías C, Fernández J, Jiménez J, Lumbreras P, Méndez G, Mulet X, Pérez-Palacios P, Rodríguez-Sánchez B, Cantón R, Hrabák J, Mancera L, Martínez-Martínez L, Oliver A, Pascual Á, Verroken A, Bou G, Oviaño M. Gato E, et al. Front Microbiol. 2022 Jan 27;12:789731. doi: 10.3389/fmicb.2021.789731. eCollection 2021. Front Microbiol. 2022. PMID: 35154029 Free PMC article.
Selection of AmpC β-Lactamase Variants and Metallo-β-Lactamases Leading to Ceftolozane/Tazobactam and Ceftazidime/Avibactam Resistance during Treatment of MDR/XDR Pseudomonas aeruginosa Infections.
Ruedas-López A, Alonso-García I, Lasarte-Monterrubio C, Guijarro-Sánchez P, Gato E, Vázquez-Ucha JC, Vallejo JA, Fraile-Ribot PA, Fernández-Pérez B, Velasco D, Gutiérrez-Urbón JM, Oviaño M, Beceiro A, González-Bello C, Oliver A, Arca-Suárez J, Bou G. Ruedas-López A, et al. Among authors: gato e. Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0206721. doi: 10.1128/AAC.02067-21. Epub 2021 Dec 20. Antimicrob Agents Chemother. 2022. PMID: 34930034 Free PMC article.
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