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Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake.
Chen SY, Beretta M, Alexopoulos SJ, Shah DP, Olzomer EM, Hargett SR, Childress ES, Salamoun JM, Aleksovska I, Roseblade A, Cranfield C, Rawling T, Quinlan KGR, Morris MJ, Tucker SP, Santos WL, Hoehn KL. Chen SY, et al. Among authors: childress es. Metabolism. 2021 Apr;117:154724. doi: 10.1016/j.metabol.2021.154724. Epub 2021 Feb 4. Metabolism. 2021. PMID: 33548253
Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress.
Byrne FL, Olzomer EM, Marriott GR, Quek LE, Katen A, Su J, Nelson ME, Hart-Smith G, Larance M, Sebesfi VF, Cuff J, Martyn GE, Childress E, Alexopoulos SJ, Poon IK, Faux MC, Burgess AW, Reid G, McCarroll JA, Santos WL, Quinlan KG, Turner N, Fazakerley DJ, Kumar N, Hoehn KL. Byrne FL, et al. Redox Biol. 2020 Jan;28:101374. doi: 10.1016/j.redox.2019.101374. Epub 2019 Nov 5. Redox Biol. 2020. PMID: 31743887 Free PMC article.
Corrigendum to "Design, synthesis and biological evaluation of glucose metabolism inhibitors as anticancer agents" [Bioorg. Chem. 151 (2024) 107665].
Cheng Y, Jones JP, Yu TT, Olzomer EM, Su J, Katen A, Black DS, Hart-Smith G, Childress ES, Beretta M, Wilkins MR, Mateos IA, Santos WL, Hoehn KL, Byrne FL, Kumar N. Cheng Y, et al. Among authors: childress es. Bioorg Chem. 2024 Oct;151:107725. doi: 10.1016/j.bioorg.2024.107725. Epub 2024 Aug 19. Bioorg Chem. 2024. PMID: 39164138 No abstract available.
VU6007477, a Novel M1 PAM Based on a Pyrrolo[2,3-b]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events.
Engers JL, Childress ES, Long MF, Capstick RA, Luscombe VB, Cho HP, Dickerson JW, Rook JM, Blobaum AL, Niswender CM, Engers DW, Conn PJ, Lindsley CW. Engers JL, et al. Among authors: childress es. ACS Med Chem Lett. 2018 Sep 4;9(9):917-922. doi: 10.1021/acsmedchemlett.8b00261. eCollection 2018 Sep 13. ACS Med Chem Lett. 2018. PMID: 30258541 Free PMC article.
19 results