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Pharmacological inhibition of IKKβ dampens NLRP3 inflammasome activation after priming in the human myeloid cell line THP-1.
Unterreiner A, Rubert J, Kauffmann M, Fruhauf A, Heiser D, Erbel P, Schlapbach A, Eder J, Bodendorf U, Boettcher A, Farady CJ, Bornancin F. Unterreiner A, et al. Among authors: bornancin f. Biochem Biophys Res Commun. 2021 Mar 19;545:177-182. doi: 10.1016/j.bbrc.2021.01.051. Epub 2021 Feb 6. Biochem Biophys Res Commun. 2021. PMID: 33561652
Cleavage by MALT1 induces cytosolic release of A20.
Malinverni C, Unterreiner A, Staal J, Demeyer A, Galaup M, Luyten M, Beyaert R, Bornancin F. Malinverni C, et al. Among authors: bornancin f. Biochem Biophys Res Commun. 2010 Oct 1;400(4):543-7. doi: 10.1016/j.bbrc.2010.08.091. Epub 2010 Sep 20. Biochem Biophys Res Commun. 2010. PMID: 20804738
Structural determinants of MALT1 protease activity.
Wiesmann C, Leder L, Blank J, Bernardi A, Melkko S, Decock A, D'Arcy A, Villard F, Erbel P, Hughes N, Freuler F, Nikolay R, Alves J, Bornancin F, Renatus M. Wiesmann C, et al. Among authors: bornancin f. J Mol Biol. 2012 May 25;419(1-2):4-21. doi: 10.1016/j.jmb.2012.02.018. Epub 2012 Feb 23. J Mol Biol. 2012. PMID: 22366302 Free article.
The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition.
Bardet M, Unterreiner A, Malinverni C, Lafossas F, Vedrine C, Boesch D, Kolb Y, Kaiser D, Glück A, Schneider MA, Katopodis A, Renatus M, Simic O, Schlapbach A, Quancard J, Régnier CH, Bold G, Pissot-Soldermann C, Carballido JM, Kovarik J, Calzascia T, Bornancin F. Bardet M, et al. Among authors: bornancin f. Immunol Cell Biol. 2018 Jan;96(1):81-99. doi: 10.1111/imcb.1018. Epub 2017 Dec 21. Immunol Cell Biol. 2018. PMID: 29359407
A CARD10-Dependent Tonic Signalosome Activates MALT1 Paracaspase and Regulates IL-17/TNF-α-Driven Keratinocyte Inflammation.
Israël L, Bardet M, Huppertz A, Mercado N, Ginster S, Unterreiner A, Schlierf A, Goetschy JF, Zerwes HG, Roth L, Kolbinger F, Bornancin F. Israël L, et al. Among authors: bornancin f. J Invest Dermatol. 2018 Sep;138(9):2075-2079. doi: 10.1016/j.jid.2018.03.1503. Epub 2018 Mar 20. J Invest Dermatol. 2018. PMID: 29571942 Free article. No abstract available.
N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.
Schlapbach A, Revesz L, Pissot Soldermann C, Zoller T, Régnier CH, Bornancin F, Radimerski T, Blank J, Schuffenhauer A, Renatus M, Erbel P, Melkko S, Heng R, Simic O, Endres R, Wartmann M, Quancard J. Schlapbach A, et al. Among authors: bornancin f. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2153-2158. doi: 10.1016/j.bmcl.2018.05.017. Epub 2018 May 9. Bioorg Med Chem Lett. 2018. PMID: 29759726
MALT1 activation by TRAF6 needs neither BCL10 nor CARD11.
Bardet M, Seeholzer T, Unterreiner A, Woods S, Krappmann D, Bornancin F. Bardet M, et al. Among authors: bornancin f. Biochem Biophys Res Commun. 2018 Nov 17;506(1):48-52. doi: 10.1016/j.bbrc.2018.10.029. Epub 2018 Oct 15. Biochem Biophys Res Commun. 2018. PMID: 30336982
75 results