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Expanding the spectrum of germline variants in cancer.
Siraj AK, Masoodi T, Bu R, Parvathareddy SK, Al-Badawi IA, Al-Sanea N, Ashari LH, Abduljabbar A, Alhomoud S, Al-Sobhi SS, Tulbah A, Ajarim D, Alzoman K, Aljuboury M, Yousef HB, Al-Dawish M, Al-Dayel F, Alkuraya FS, Al-Kuraya KS. Siraj AK, et al. Among authors: parvathareddy sk. Hum Genet. 2017 Nov;136(11-12):1431-1444. doi: 10.1007/s00439-017-1845-0. Epub 2017 Oct 3. Hum Genet. 2017. PMID: 28975465
FoxM1 and β-catenin predicts aggressiveness in Middle Eastern ovarian cancer and their co-targeting impairs the growth of ovarian cancer cells.
Pratheeshkumar P, Divya SP, Parvathareddy SK, Alhoshani NM, Al-Badawi IA, Tulbah A, Al-Dayel F, Siraj AK, Al-Kuraya KS. Pratheeshkumar P, et al. Among authors: parvathareddy sk. Oncotarget. 2017 Dec 16;9(3):3590-3604. doi: 10.18632/oncotarget.23338. eCollection 2018 Jan 9. Oncotarget. 2017. PMID: 29423068 Free PMC article.
Overexpression of PARP is an independent prognostic marker for poor survival in Middle Eastern breast cancer and its inhibition can be enhanced with embelin co-treatment.
Siraj AK, Pratheeshkumar P, Parvathareddy SK, Divya SP, Al-Dayel F, Tulbah A, Ajarim D, Al-Kuraya KS. Siraj AK, et al. Among authors: parvathareddy sk. Oncotarget. 2018 Dec 18;9(99):37319-37332. doi: 10.18632/oncotarget.26470. eCollection 2018 Dec 18. Oncotarget. 2018. PMID: 30647872 Free PMC article.
TGFβ-induced SMAD4-dependent Apoptosis Proceeded by EMT in CRC.
Siraj AK, Pratheeshkumar P, Divya SP, Parvathareddy SK, Bu R, Masoodi T, Kong Y, Thangavel S, Al-Sanea N, Ashari LH, Abduljabbar A, Al-Homoud S, Al-Dayel F, Al-Kuraya KS. Siraj AK, et al. Among authors: parvathareddy sk. Mol Cancer Ther. 2019 Jul;18(7):1312-1322. doi: 10.1158/1535-7163.MCT-18-1378. Epub 2019 May 3. Mol Cancer Ther. 2019. PMID: 31053577
60 results