Brockmöller J - Search Results

1

Identification of Novel High-Affinity Substrates of OCT1 Using Machine Learning-Guided Virtual Screening and Experimental Validation.

Jensen O, Brockmöller J, Dücker C. Jensen O, et al. Among authors: brockmoller j. J Med Chem. 2021 Mar 11;64(5):2762-2776. doi: 10.1021/acs.jmedchem.0c02047. Epub 2021 Feb 19. J Med Chem. 2021. PMID: 33606526

2

OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics.

Matthaei J, Kuron D, Faltraco F, Knoch T, Dos Santos Pereira JN, Abu Abed M, Prukop T, Brockmöller J, Tzvetkov MV. Matthaei J, et al. Among authors: brockmoller j. Clin Pharmacol Ther. 2016 Jun;99(6):633-41. doi: 10.1002/cpt.317. Epub 2016 Jan 12. Clin Pharmacol Ther. 2016. PMID: 26659468

3

Increased Systemic Exposure and Stronger Cardiovascular and Metabolic Adverse Reactions to Fenoterol in Individuals with Heritable OCT1 Deficiency.

Tzvetkov MV, Matthaei J, Pojar S, Faltraco F, Vogler S, Prukop T, Seitz T, Brockmöller J. Tzvetkov MV, et al. Among authors: brockmoller j. Clin Pharmacol Ther. 2018 May;103(5):868-878. doi: 10.1002/cpt.812. Epub 2017 Dec 8. Clin Pharmacol Ther. 2018. PMID: 28791698 Clinical Trial.

4

Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine.

Meyer MJ, Seitz T, Brockmöller J, Tzvetkov MV. Meyer MJ, et al. Among authors: brockmoller j. PLoS One. 2017 Dec 13;12(12):e0189521. doi: 10.1371/journal.pone.0189521. eCollection 2017. PLoS One. 2017. PMID: 29236753 Free PMC article.

5

Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age- vs. Genotype-Related Differences.

Dücker CM, Brockmöller J. Dücker CM, et al. Among authors: brockmoller j. Clin Pharmacol Ther. 2019 Mar;105(3):625-640. doi: 10.1002/cpt.1057. Epub 2018 Apr 2. Clin Pharmacol Ther. 2019. PMID: 29498032 Free PMC article. Review.

6

OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil.

Matthaei J, Seitz T, Jensen O, Tann A, Prukop T, Tadjerpisheh S, Brockmöller J, Tzvetkov MV. Matthaei J, et al. Among authors: brockmoller j. Clin Pharmacol Ther. 2019 Jan;105(1):190-200. doi: 10.1002/cpt.1128. Epub 2018 Aug 1. Clin Pharmacol Ther. 2019. PMID: 29882324 Clinical Trial.

7

Variability and Heritability of Thiamine Pharmacokinetics With Focus on OCT1 Effects on Membrane Transport and Pharmacokinetics in Humans.

Jensen O, Matthaei J, Blome F, Schwab M, Tzvetkov MV, Brockmöller J. Jensen O, et al. Among authors: brockmoller j. Clin Pharmacol Ther. 2020 Mar;107(3):628-638. doi: 10.1002/cpt.1666. Epub 2019 Nov 23. Clin Pharmacol Ther. 2020. PMID: 31593619

8

Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1.

Meyer MJ, Neumann VE, Friesacher HR, Zdrazil B, Brockmöller J, Tzvetkov MV. Meyer MJ, et al. Among authors: brockmoller j. J Med Chem. 2019 Nov 14;62(21):9890-9905. doi: 10.1021/acs.jmedchem.9b01301. Epub 2019 Nov 4. J Med Chem. 2019. PMID: 31597043

9

Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A.

Rafehi M, Faltraco F, Matthaei J, Prukop T, Jensen O, Grytzmann A, Blome FG, Berger RG, Krings U, Vormfelde SV, Tzvetkov MV, Brockmöller J. Rafehi M, et al. Among authors: brockmoller j. Front Pharmacol. 2019 Oct 30;10:1297. doi: 10.3389/fphar.2019.01297. eCollection 2019. Front Pharmacol. 2019. PMID: 31736764 Free PMC article.

10

Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters.

Jensen O, Rafehi M, Tzvetkov MV, Brockmöller J. Jensen O, et al. Among authors: brockmoller j. Biochem Pharmacol. 2020 Jan;171:113731. doi: 10.1016/j.bcp.2019.113731. Epub 2019 Nov 27. Biochem Pharmacol. 2020. PMID: 31783011

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