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Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease.
Horowitz JE, Kosmicki JA, Damask A, Sharma D, Roberts GHL, Justice AE, Banerjee N, Coignet MV, Yadav A, Leader JB, Marcketta A, Park DS, Lanche R, Maxwell E, Knight SC, Bai X, Guturu H, Sun D, Baltzell A, Kury FSP, Backman JD, Girshick AR, O'Dushlaine C, McCurdy SR, Partha R, Mansfield AJ, Turissini DA, Li AH, Zhang M, Mbatchou J, Watanabe K, Gurski L, McCarthy SE, Kang HM, Dobbyn L, Stahl E, Verma A, Sirugo G; Regeneron Genetics Center; Ritchie MD, Jones M, Balasubramanian S, Siminovitch K, Salerno WJ, Shuldiner AR, Rader DJ, Mirshahi T, Locke AE, Marchini J, Overton JD, Carey DJ, Habegger L, Cantor MN, Rand KA, Hong EL, Reid JG, Ball CA, Baras A, Abecasis GR, Ferreira MA. Horowitz JE, et al. Among authors: turissini da. medRxiv [Preprint]. 2021 Jun 10:2020.12.14.20248176. doi: 10.1101/2020.12.14.20248176. medRxiv. 2021. Update in: Nat Genet. 2022 Apr;54(4):382-392. doi: 10.1038/s41588-021-01006-7 PMID: 33619501 Free PMC article. Updated. Preprint.
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease.
Horowitz JE, Kosmicki JA, Damask A, Sharma D, Roberts GHL, Justice AE, Banerjee N, Coignet MV, Yadav A, Leader JB, Marcketta A, Park DS, Lanche R, Maxwell E, Knight SC, Bai X, Guturu H, Sun D, Baltzell A, Kury FSP, Backman JD, Girshick AR, O'Dushlaine C, McCurdy SR, Partha R, Mansfield AJ, Turissini DA, Li AH, Zhang M, Mbatchou J, Watanabe K, Gurski L, McCarthy SE, Kang HM, Dobbyn L, Stahl E, Verma A, Sirugo G; Regeneron Genetics Center; Ritchie MD, Jones M, Balasubramanian S, Siminovitch K, Salerno WJ, Shuldiner AR, Rader DJ, Mirshahi T, Locke AE, Marchini J, Overton JD, Carey DJ, Habegger L, Cantor MN, Rand KA, Hong EL, Reid JG, Ball CA, Baras A, Abecasis GR, Ferreira MAR. Horowitz JE, et al. Among authors: turissini da. Nat Genet. 2022 Apr;54(4):382-392. doi: 10.1038/s41588-021-01006-7. Epub 2022 Mar 3. Nat Genet. 2022. PMID: 35241825 Free PMC article.
COVID-19 susceptibility and severity risks in a cross-sectional survey of over 500 000 US adults.
Knight SC, McCurdy SR, Rhead B, Coignet MV, Park DS, Roberts GHL, Berkowitz ND, Zhang M, Turissini D, Delgado K, Pavlovic M; AncestryDNA Science Team; Haug Baltzell AK, Guturu H, Rand KA, Girshick AR, Hong EL, Ball CA. Knight SC, et al. BMJ Open. 2022 Oct 12;12(10):e049657. doi: 10.1136/bmjopen-2021-049657. BMJ Open. 2022. PMID: 36223959 Free PMC article.
Ancestry inference using reference labeled clusters of haplotypes.
Wang Y, Song S, Schraiber JG, Sedghifar A, Byrnes JK, Turissini DA, Hong EL, Ball CA, Noto K. Wang Y, et al. Among authors: turissini da. BMC Bioinformatics. 2021 Sep 25;22(1):459. doi: 10.1186/s12859-021-04350-x. BMC Bioinformatics. 2021. PMID: 34563119 Free PMC article.
Adaptive genic evolution in the Drosophila genomes.
Shapiro JA, Huang W, Zhang C, Hubisz MJ, Lu J, Turissini DA, Fang S, Wang HY, Hudson RR, Nielsen R, Chen Z, Wu CI. Shapiro JA, et al. Among authors: turissini da. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2271-6. doi: 10.1073/pnas.0610385104. Epub 2007 Feb 6. Proc Natl Acad Sci U S A. 2007. PMID: 17284599 Free PMC article.
A locus in Drosophila sechellia affecting tolerance of a host plant toxin.
Hungate EA, Earley EJ, Boussy IA, Turissini DA, Ting CT, Moran JR, Wu ML, Wu CI, Jones CD. Hungate EA, et al. Among authors: turissini da. Genetics. 2013 Nov;195(3):1063-75. doi: 10.1534/genetics.113.154773. Epub 2013 Sep 13. Genetics. 2013. PMID: 24037270 Free PMC article.
24 results