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Discovery of Anthranilic Acid Derivatives as Antagonists of the Pro-Inflammatory Orphan G Protein-Coupled Receptor GPR17.
Boshta NM, Lewash M, Köse M, Namasivayam V, Sarkar S, Voss JH, Liedtke AJ, Junker A, Tian M, Stößel A, Rashed M, Mahal A, Merten N, Pegurier C, Hockemeyer J, Kostenis E, Müller CE. Boshta NM, et al. Among authors: muller ce. J Med Chem. 2024 Nov 14;67(21):19365-19394. doi: 10.1021/acs.jmedchem.4c01755. Epub 2024 Nov 1. J Med Chem. 2024. PMID: 39484825
SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor.
Alnouri MW, Roquid KA, Bonnavion R, Cho H, Heering J, Kwon J, Jäger Y, Wang S, Günther S, Wettschureck N, Geisslinger G, Gurke R, Müller CE, Proschak E, Offermanns S. Alnouri MW, et al. Among authors: muller ce. Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2407130121. doi: 10.1073/pnas.2407130121. Epub 2024 Oct 4. Proc Natl Acad Sci U S A. 2024. PMID: 39365815 Free PMC article.
Miniaturized Modular Click Chemistry-enabled Rapid Discovery of Unique SARS-CoV-2 Mpro Inhibitors With Robust Potency and Drug-like Profile.
Yang M, Lee MK, Gao S, Song L, Jang HY, Jo I, Yang CC, Sylvester K, Ko C, Wang S, Ye B, Tang K, Li J, Gu M, Müller CE, Sträter N, Liu X, Kim M, Zhan P. Yang M, et al. Among authors: muller ce. Adv Sci (Weinh). 2024 Nov;11(43):e2404884. doi: 10.1002/advs.202404884. Epub 2024 Sep 25. Adv Sci (Weinh). 2024. PMID: 39319611 Free PMC article.
571 results