Zhan D - Search Results

1

Development of a targeted integration Chinese hamster ovary host directly targeting either one or two vectors simultaneously to a single locus using the Cre/Lox recombinase-mediated cassette exchange system.

Ng D, Zhou M, Zhan D, Yip S, Ko P, Yim M, Modrusan Z, Joly J, Snedecor B, Laird MW, Shen A. Ng D, et al. Among authors: zhan d. Biotechnol Prog. 2021 Jul;37(4):e3140. doi: 10.1002/btpr.3140. Epub 2021 Apr 9. Biotechnol Prog. 2021. PMID: 33666334

2

Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell.

Hu Z, Guo D, Yip SS, Zhan D, Misaghi S, Joly JC, Snedecor BR, Shen AY. Hu Z, et al. Among authors: zhan d. Biotechnol Prog. 2013 Jul-Aug;29(4):980-5. doi: 10.1002/btpr.1730. Epub 2013 Apr 18. Biotechnol Prog. 2013. PMID: 23606666

3

Probing the importance of clonality: Single cell subcloning of clonally derived CHO cell lines yields widely diverse clones differing in growth, productivity, and product quality.

Ko P, Misaghi S, Hu Z, Zhan D, Tsukuda J, Yim M, Sanford M, Shaw D, Shiratori M, Snedecor B, Laird M, Shen A. Ko P, et al. Among authors: zhan d. Biotechnol Prog. 2018 May;34(3):624-634. doi: 10.1002/btpr.2594. Epub 2017 Dec 27. Biotechnol Prog. 2018. PMID: 29226566

4

Maximizing antibody production in a targeted integration host by optimization of subunit gene dosage and position.

Carver J, Ng D, Zhou M, Ko P, Zhan D, Yim M, Shaw D, Snedecor B, Laird MW, Lang S, Shen A, Hu Z. Carver J, et al. Among authors: zhan d. Biotechnol Prog. 2020 Jul;36(4):e2967. doi: 10.1002/btpr.2967. Epub 2020 Feb 17. Biotechnol Prog. 2020. PMID: 31965756

5

High Intracellular Seed Train BiP Levels Correlate With Poor Production Culture Performance in CHO Cells.

Tung M, Tang D, Wang SH, Zhan D, Kiplinger K, Pan S, Jing Y, Shen A, Ahyow P, Snedecor B, Gawlitzek M, Misaghi S. Tung M, et al. Among authors: zhan d. Biotechnol J. 2018 Oct;13(10):e1700746. doi: 10.1002/biot.201700746. Epub 2018 Apr 24. Biotechnol J. 2018. PMID: 29635750

6

Role of surface exposed tryptophan as substrate generators for the antibody catalyzed water oxidation pathway.

Sreedhara A, Lau K, Li C, Hosken B, Macchi F, Zhan D, Shen A, Steinmann D, Schöneich C, Lentz Y. Sreedhara A, et al. Among authors: zhan d. Mol Pharm. 2013 Jan 7;10(1):278-88. doi: 10.1021/mp300418r. Epub 2012 Nov 26. Mol Pharm. 2013. PMID: 23136850

7

Tailoring translational strength using Kozak sequence variants improves bispecific antibody assembly and reduces product-related impurities in CHO cells.

Blanco N, Williams AJ, Tang D, Zhan D, Misaghi S, Kelley RF, Simmons LC. Blanco N, et al. Among authors: zhan d. Biotechnol Bioeng. 2020 Jul;117(7):1946-1960. doi: 10.1002/bit.27347. Epub 2020 Apr 21. Biotechnol Bioeng. 2020. PMID: 32246763

8

Detection of minute virus of mice using real time quantitative PCR in assessment of virus clearance during the purification of Mammalian cell substrate derived biotherapeutics.

Zhan D, Roy MR, Valera C, Cardenas J, Vennari JC, Chen JW, Liu S. Zhan D, et al. Biologicals. 2002 Dec;30(4):259-70. doi: 10.1006/biol.2001.0284. Biologicals. 2002. PMID: 12421584

9

Binding of the human papillomavirus type 16 p97 promoter by the adeno-associated virus Rep78 major regulatory protein correlates with inhibition.

Zhan D, Santin AD, Liu Y, Parham GP, Li C, Meyers C, Hermonat PL. Zhan D, et al. J Biol Chem. 1999 Oct 29;274(44):31619-24. doi: 10.1074/jbc.274.44.31619. J Biol Chem. 1999. PMID: 10531369 Free article.

10

The adeno-associated virus major regulatory protein Rep78-c-Jun-DNA motif complex modulates AP-1 activity.

Prasad CK, Meyers C, Zhan DJ, You H, Chiriva-Internati M, Mehta JL, Liu Y, Hermonat PL. Prasad CK, et al. Virology. 2003 Sep 15;314(1):423-31. doi: 10.1016/s0042-6822(03)00439-2. Virology. 2003. PMID: 14517094 Free article.

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