Metabolic Abnormalities of Chronic High-Dose Glucocorticoids Are Not Mediated by Hypothalamic AgRP in Male Mice.
Sefton C, Davies A, Allen TJ, Wray JR, Shoop R, Adamson A, Humphreys N, Coll AP, White A, Harno E.
Sefton C, et al. Among authors: white a.
Endocrinology. 2019 May 1;160(5):964-978. doi: 10.1210/en.2019-00018.
Endocrinology. 2019.
PMID: 30794724
Free PMC article.
Glucocorticoids are potent and widely used medicines but often cause metabolic side effects. A murine model of corticosterone treatment resulted in increased hypothalamic expression of the melanocortin antagonist AgRP in parallel with obesity and hyperglycemia. ...Phenotyp …
Glucocorticoids are potent and widely used medicines but often cause metabolic side effects. A murine model of corticosterone treatme …