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Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites.
Tokarew JM, El-Kodsi DN, Lengacher NA, Fehr TK, Nguyen AP, Shutinoski B, O'Nuallain B, Jin M, Khan JM, Ng ACH, Li J, Jiang Q, Zhang M, Wang L, Sengupta R, Barber KR, Tran A, Im DS, Callaghan S, Park DS, Zandee S, Dong X, Scherzer CR, Prat A, Tsai EC, Takanashi M, Hattori N, Chan JA, Zecca L, West AB, Holmgren A, Puente L, Shaw GS, Toth G, Woulfe JM, Taylor P, Tomlinson JJ, Schlossmacher MG. Tokarew JM, et al. Among authors: barber kr. Acta Neuropathol. 2021 May;141(5):725-754. doi: 10.1007/s00401-021-02285-4. Epub 2021 Mar 10. Acta Neuropathol. 2021. PMID: 33694021 Free PMC article.
Ataxin-3 is a multivalent ligand for the parkin Ubl domain.
Bai JJ, Safadi SS, Mercier P, Barber KR, Shaw GS. Bai JJ, et al. Among authors: barber kr. Biochemistry. 2013 Oct 22;52(42):7369-76. doi: 10.1021/bi400780v. Epub 2013 Oct 9. Biochemistry. 2013. PMID: 24063750 Free PMC article.
Ubiquitin phosphorylated at Ser57 hyper-activates parkin.
George S, Wang SM, Bi Y, Treidlinger M, Barber KR, Shaw GS, O'Donoghue P. George S, et al. Among authors: barber kr. Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt B):3038-3046. doi: 10.1016/j.bbagen.2017.06.023. Epub 2017 Jul 6. Biochim Biophys Acta Gen Subj. 2017. PMID: 28689991
Solution structure of the E3 ligase HOIL-1 Ubl domain.
Beasley SA, Safadi SS, Barber KR, Shaw GS. Beasley SA, et al. Among authors: barber kr. Protein Sci. 2012 Jul;21(7):1085-92. doi: 10.1002/pro.2080. Epub 2012 May 24. Protein Sci. 2012. PMID: 22517668 Free PMC article.
115 results