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Page 1
Debaryomyces is enriched in Crohn's disease intestinal tissue and impairs healing in mice.
Jain U, Ver Heul AM, Xiong S, Gregory MH, Demers EG, Kern JT, Lai CW, Muegge BD, Barisas DAG, Leal-Ekman JS, Deepak P, Ciorba MA, Liu TC, Hogan DA, Debbas P, Braun J, McGovern DPB, Underhill DM, Stappenbeck TS. Jain U, et al. Among authors: kern jt. Science. 2021 Mar 12;371(6534):1154-1159. doi: 10.1126/science.abd0919. Science. 2021. PMID: 33707263 Free PMC article.
Autophagy proteins are required for club cell structure and function in airways.
Malvin NP, Kern JT, Liu TC, Brody SL, Stappenbeck TS. Malvin NP, et al. Among authors: kern jt. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 1;317(2):L259-L270. doi: 10.1152/ajplung.00394.2018. Epub 2019 May 22. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 31116580 Free PMC article.
Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation.
Liu TC, Kern JT, Jain U, Sonnek NM, Xiong S, Simpson KF, VanDussen KL, Winkler ES, Haritunians T, Malique A, Lu Q, Sasaki Y, Storer C, Diamond MS, Head RD, McGovern DPB, Stappenbeck TS. Liu TC, et al. Among authors: kern jt. Cell Host Microbe. 2021 Jun 9;29(6):988-1001.e6. doi: 10.1016/j.chom.2021.04.004. Epub 2021 May 18. Cell Host Microbe. 2021. PMID: 34010595 Free PMC article.
Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction.
Sun S, Hodel M, Wang X, De Vicente J, Haritunians T, Debebe A, Hung CT, Ma C, Malique A, Nguyen HN, Agam M, Maloney MT, Goo MS, Kluss JH, Mishra R, Frein J, Foster A, Ballentine S, Pandey U, Kern J, Yang S, Mengesha E, Balasubramanian I, Arguello A, Estrada AA, Gao N, Peter I, McGovern DPB, Henry AG, Stappenbeck TS, Liu TC. Sun S, et al. Sci Immunol. 2024 Nov 8;9(101):eadi7907. doi: 10.1126/sciimmunol.adi7907. Epub 2024 Nov 8. Sci Immunol. 2024. PMID: 39514635 Free PMC article.
Tubular CPT1A deletion minimally affects aging and chronic kidney injury.
Hammoud S, Ivanova A, Osaki Y, Funk S, Yang H, Viquez O, Delgado R, Lu D, Phillips Mignemi M, Tonello J, Colon S, Lantier L, Wasserman DH, Humphreys BD, Koenitzer J, Kern J, de Caestecker M, Finkel T, Fogo A, Messias N, Lodhi IJ, Gewin LS. Hammoud S, et al. JCI Insight. 2024 Feb 22;9(6):e171961. doi: 10.1172/jci.insight.171961. JCI Insight. 2024. PMID: 38516886 Free PMC article.
Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator.
Rudd MT, Manley PJ, Hanney B, Meng Z, Shu Y, de Leon P, Frie JL, Han Y, Wai JM, Yang ZQ, Perkins JJ, Hurzy DM, Manikowski JJ, Zhu H, Bungard CJ, Converso A, Meissner RS, Cosden ML, Hayashi I, Ma L, O'Brien J, Uebele VN, Schachter JB, Bhandari N, Ward GJ, Fillgrove KL, Lu B, Liang Y, Dubost DC, Puri V, Eddins DM, Vardigan JD, Drolet RE, Kern JT, Uslaner JM. Rudd MT, et al. Among authors: kern jt. ACS Med Chem Lett. 2023 Jul 12;14(8):1088-1094. doi: 10.1021/acsmedchemlett.3c00210. eCollection 2023 Aug 10. ACS Med Chem Lett. 2023. PMID: 37583812 Free PMC article.
26 results