Rakiec DP - Search Results

1

RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation.

Crowe MS, Zavorotinskaya T, Voliva CF, Shirley MD, Wang Y, Ruddy DA, Rakiec DP, Engelman JA, Stuart DD, Freeman AK. Crowe MS, et al. Among authors: rakiec dp. Mol Cancer Res. 2021 Jun;19(6):1063-1075. doi: 10.1158/1541-7786.MCR-20-1022. Epub 2021 Mar 11. Mol Cancer Res. 2021. PMID: 33707308

2

BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity.

Emery CM, Monaco KA, Wang P, Balak M, Freeman A, Meltzer J, Delach SM, Rakiec D, Ruddy DA, Korn JM, Haling J, Acker MG, Caponigro G. Emery CM, et al. Mol Cancer Res. 2017 Oct;15(10):1431-1444. doi: 10.1158/1541-7786.MCR-17-0211. Epub 2017 Jun 27. Mol Cancer Res. 2017. PMID: 28655712

3

Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma.

Leung GP, Feng T, Sigoillot FD, Geyer FC, Shirley MD, Ruddy DA, Rakiec DP, Freeman AK, Engelman JA, Jaskelioff M, Stuart DD. Leung GP, et al. Among authors: rakiec dp. Mol Cancer Res. 2019 Jan;17(1):199-211. doi: 10.1158/1541-7786.MCR-18-0327. Epub 2018 Sep 10. Mol Cancer Res. 2019. PMID: 30201825

4

Distinct Transcriptional Programming Drive Response to MAPK Inhibition in BRAF ^V600-Mutant Melanoma Patient-Derived Xenografts.

Feng T, Golji J, Li A, Zhang X, Ruddy DA, Rakiec DP, Geyer FC, Gu J, Gao H, Williams JA, Stuart DD, Meyer MJ. Feng T, et al. Among authors: rakiec dp. Mol Cancer Ther. 2019 Dec;18(12):2421-2432. doi: 10.1158/1535-7163.MCT-19-0028. Epub 2019 Sep 16. Mol Cancer Ther. 2019. PMID: 31527224

5

A chemical genetics approach for the functional assessment of novel cancer genes.

Zhou Q, Derti A, Ruddy D, Rakiec D, Kao I, Lira M, Gibaja V, Chan H, Yang Y, Min J, Schlabach MR, Stegmeier F. Zhou Q, et al. Cancer Res. 2015 May 15;75(10):1949-58. doi: 10.1158/0008-5472.CAN-14-2930. Epub 2015 Mar 18. Cancer Res. 2015. PMID: 25788694

6

Inhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non-Small Cell Lung Cancer.

Lantermann AB, Chen D, McCutcheon K, Hoffman G, Frias E, Ruddy D, Rakiec D, Korn J, McAllister G, Stegmeier F, Meyer MJ, Sharma SV. Lantermann AB, et al. Cancer Res. 2015 Nov 15;75(22):4937-48. doi: 10.1158/0008-5472.CAN-15-1113. Epub 2015 Oct 21. Cancer Res. 2015. PMID: 26490646

7

FGFR-Mediated Reactivation of MAPK Signaling Attenuates Antitumor Effects of Imatinib in Gastrointestinal Stromal Tumors.

Li F, Huynh H, Li X, Ruddy DA, Wang Y, Ong R, Chow P, Qiu S, Tam A, Rakiec DP, Schlegel R, Monahan JE, Huang A. Li F, et al. Among authors: rakiec dp. Cancer Discov. 2015 Apr;5(4):438-51. doi: 10.1158/2159-8290.CD-14-0763. Epub 2015 Feb 11. Cancer Discov. 2015. PMID: 25673643

8

A Proof of Concept for Biomarker-Guided Targeted Therapy against Ovarian Cancer Based on Patient-Derived Tumor Xenografts.

Palmer AC, Plana D, Gao H, Korn JM, Yang G, Green J, Zhang X, Velazquez R, McLaughlin ME, Ruddy DA, Kowal C, Muszynski J, Bullock C, Rivera S, Rakiec DP, Elliott G, Fordjour P, Meyer R, Loo A, Kurth E, Engelman JA, Bitter H, Sellers WR, Williams JA, Sorger PK. Palmer AC, et al. Among authors: rakiec dp. Cancer Res. 2020 Oct 1;80(19):4278-4287. doi: 10.1158/0008-5472.CAN-19-3850. Epub 2020 Aug 3. Cancer Res. 2020. PMID: 32747364 Free PMC article.

9

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions.

Munoz DM, Cassiani PJ, Li L, Billy E, Korn JM, Jones MD, Golji J, Ruddy DA, Yu K, McAllister G, DeWeck A, Abramowski D, Wan J, Shirley MD, Neshat SY, Rakiec D, de Beaumont R, Weber O, Kauffmann A, McDonald ER 3rd, Keen N, Hofmann F, Sellers WR, Schmelzle T, Stegmeier F, Schlabach MR. Munoz DM, et al. Cancer Discov. 2016 Aug;6(8):900-13. doi: 10.1158/2159-8290.CD-16-0178. Epub 2016 Jun 3. Cancer Discov. 2016. PMID: 27260157

10

An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide).

Korpal M, Korn JM, Gao X, Rakiec DP, Ruddy DA, Doshi S, Yuan J, Kovats SG, Kim S, Cooke VG, Monahan JE, Stegmeier F, Roberts TM, Sellers WR, Zhou W, Zhu P. Korpal M, et al. Among authors: rakiec dp. Cancer Discov. 2013 Sep;3(9):1030-43. doi: 10.1158/2159-8290.CD-13-0142. Epub 2013 Jul 10. Cancer Discov. 2013. PMID: 23842682

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