Mitchell DA - Search Results

1

Functional elucidation of TfuA in peptide backbone thioamidation.

Liu A, Si Y, Dong SH, Mahanta N, Penkala HN, Nair SK, Mitchell DA. Liu A, et al. Among authors: mitchell da. Nat Chem Biol. 2021 May;17(5):585-592. doi: 10.1038/s41589-021-00771-0. Epub 2021 Mar 11. Nat Chem Biol. 2021. PMID: 33707784 Free PMC article.

2

YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations.

Dunbar KL, Melby JO, Mitchell DA. Dunbar KL, et al. Among authors: mitchell da. Nat Chem Biol. 2012 Apr 22;8(6):569-75. doi: 10.1038/nchembio.944. Nat Chem Biol. 2012. PMID: 22522320 Free PMC article.

3

Engineering unnatural variants of plantazolicin through codon reprogramming.

Deane CD, Melby JO, Molohon KJ, Susarrey AR, Mitchell DA. Deane CD, et al. Among authors: mitchell da. ACS Chem Biol. 2013 Sep 20;8(9):1998-2008. doi: 10.1021/cb4003392. Epub 2013 Jul 3. ACS Chem Biol. 2013. PMID: 23823732 Free PMC article.

4

Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis.

Lee J, Hao Y, Blair PM, Melby JO, Agarwal V, Burkhart BJ, Nair SK, Mitchell DA. Lee J, et al. Among authors: mitchell da. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):12954-9. doi: 10.1073/pnas.1306101110. Epub 2013 Jul 22. Proc Natl Acad Sci U S A. 2013. PMID: 23878226 Free PMC article.

5

Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis.

Dunbar KL, Chekan JR, Cox CL, Burkhart BJ, Nair SK, Mitchell DA. Dunbar KL, et al. Among authors: mitchell da. Nat Chem Biol. 2014 Oct;10(10):823-9. doi: 10.1038/nchembio.1608. Epub 2014 Aug 17. Nat Chem Biol. 2014. PMID: 25129028 Free PMC article.

6

Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin.

Hao Y, Saint-Vincent PMB, Sharma A, Mitchell DA, Nair SK. Hao Y, et al. Among authors: mitchell da. ACS Chem Biol. 2015 May 15;10(5):1209-1216. doi: 10.1021/cb501042a. Epub 2015 Feb 11. ACS Chem Biol. 2015. PMID: 25635336 Free PMC article.

7

A prevalent peptide-binding domain guides ribosomal natural product biosynthesis.

Burkhart BJ, Hudson GA, Dunbar KL, Mitchell DA. Burkhart BJ, et al. Among authors: mitchell da. Nat Chem Biol. 2015 Aug;11(8):564-70. doi: 10.1038/nchembio.1856. Epub 2015 Jul 13. Nat Chem Biol. 2015. PMID: 26167873 Free PMC article.

8

In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products.

Deane CD, Burkhart BJ, Saint-Vincent PMB, Tietz JI, Lin A, Mitchell DA. Deane CD, et al. Among authors: mitchell da. ACS Chem Biol. 2016 Aug 19;11(8):2232-43. doi: 10.1021/acschembio.6b00369. Epub 2016 Jun 16. ACS Chem Biol. 2016. PMID: 27248686 Free PMC article.

9

Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin.

Zhang Z, Hudson GA, Mahanta N, Tietz JI, van der Donk WA, Mitchell DA. Zhang Z, et al. Among authors: mitchell da. J Am Chem Soc. 2016 Dec 7;138(48):15511-15514. doi: 10.1021/jacs.6b08987. Epub 2016 Oct 13. J Am Chem Soc. 2016. PMID: 27700071 Free PMC article.

10

A new genome-mining tool redefines the lasso peptide biosynthetic landscape.

Tietz JI, Schwalen CJ, Patel PS, Maxson T, Blair PM, Tai HC, Zakai UI, Mitchell DA. Tietz JI, et al. Among authors: mitchell da. Nat Chem Biol. 2017 May;13(5):470-478. doi: 10.1038/nchembio.2319. Epub 2017 Feb 28. Nat Chem Biol. 2017. PMID: 28244986 Free PMC article.

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