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Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits.
Rademakers R, Nicholson AM, Ren Y, Koga S, Nguyen HP, Brooks M, Qiao W, Quicksall ZS, Matchett B, Perkerson RB, Kurti A, Castanedes-Casey M, Phillips V, Librero AL, Fernandez De Castro CH, Baker MC, Roemer SF, Murray ME, Asmann Y, Fryer JD, Bu G, Dickson DW, Zhou X. Rademakers R, et al. Among authors: fernandez de castro ch. Brain Pathol. 2021 May;31(3):e12945. doi: 10.1111/bpa.12945. Epub 2021 Mar 11. Brain Pathol. 2021. PMID: 33709463 Free PMC article.
A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech.
Josephs KA, Duffy JR, Clark HM, Utianski RL, Strand EA, Machulda MM, Botha H, Martin PR, Pham NTT, Stierwalt J, Ali F, Buciuc M, Baker M, Fernandez De Castro CH, Spychalla AJ, Schwarz CG, Reid RI, Senjem ML, Jack CR Jr, Lowe VJ, Bigio EH, Reichard RR, Polley EJ, Ertekin-Taner N, Rademakers R, DeTure MA, Ross OA, Dickson DW, Whitwell JL. Josephs KA, et al. Among authors: fernandez de castro ch. Nat Commun. 2021 Jun 8;12(1):3452. doi: 10.1038/s41467-021-23687-8. Nat Commun. 2021. PMID: 34103532 Free PMC article. Clinical Trial.