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Multiple mutations in RNA polymerase β-subunit gene (rpoB) in Streptomyces incarnatus NRRL8089 enhance production of antiviral antibiotic sinefungin: modeling rif cluster region by density functional theory.
Ogawa S, Shimidzu H, Fukuda K, Tsunekawa N, Hirano T, Sato F, Yura K, Hasunuma T, Ochi K, Yamamoto M, Sakamoto W, Hashimoto K, Ogata H, Kanao T, Nemoto M, Inagaki K, Tamura T. Ogawa S, et al. Among authors: shimidzu h. Biosci Biotechnol Biochem. 2021 Apr 24;85(5):1275-1282. doi: 10.1093/bbb/zbab011. Biosci Biotechnol Biochem. 2021. PMID: 33710298