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Page 1
Protocol for rational design of covalently interacting inhibitors.
Schmidt TC, Welker A, Rieger M, Sahu PK, Sotriffer CA, Schirmeister T, Engels B. Schmidt TC, et al. Among authors: sotriffer ca. Chemphyschem. 2014 Oct 20;15(15):3226-35. doi: 10.1002/cphc.201402542. Epub 2014 Sep 24. Chemphyschem. 2014. PMID: 25251382
Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model.
Hoffmann M, Stiller C, Endres E, Scheiner M, Gunesch S, Sotriffer C, Maurice T, Decker M. Hoffmann M, et al. Among authors: sotriffer c. J Med Chem. 2019 Oct 24;62(20):9116-9140. doi: 10.1021/acs.jmedchem.9b01012. Epub 2019 Oct 14. J Med Chem. 2019. PMID: 31609115
Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2.
Welker A, Kersten C, Müller C, Madhugiri R, Zimmer C, Müller P, Zimmermann R, Hammerschmidt S, Maus H, Ziebuhr J, Sotriffer C, Schirmeister T. Welker A, et al. Among authors: sotriffer c. ChemMedChem. 2021 Jan 19;16(2):340-354. doi: 10.1002/cmdc.202000548. Epub 2020 Oct 16. ChemMedChem. 2021. PMID: 32930481 Free PMC article.
Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control of Inhibition in Vitro and Enable Restoration of Cognition in an Alzheimer's Disease Mouse Model upon Irradiation.
Scheiner M, Sink A, Hoffmann M, Vrigneau C, Endres E, Carles A, Sotriffer C, Maurice T, Decker M. Scheiner M, et al. Among authors: sotriffer c. J Am Chem Soc. 2022 Feb 23;144(7):3279-3284. doi: 10.1021/jacs.1c13492. Epub 2022 Feb 9. J Am Chem Soc. 2022. PMID: 35138833
Structural basis for the bi-specificity of USP25 and USP28 inhibitors.
Patzke JV, Sauer F, Nair RK, Endres E, Proschak E, Hernandez-Olmos V, Sotriffer C, Kisker C. Patzke JV, et al. Among authors: sotriffer c. EMBO Rep. 2024 Jul;25(7):2950-2973. doi: 10.1038/s44319-024-00167-w. Epub 2024 May 30. EMBO Rep. 2024. PMID: 38816515 Free PMC article.
112 results