Kuo CC - Search Results

1

How Can an Na⁺ Channel Inhibitor Ameliorate Seizures in Lennox-Gastaut Syndrome?

Lin YC, Lai YC, Chou P, Hsueh SW, Lin TH, Huang CS, Wang RW, Yang YC, Kuo CC. Lin YC, et al. Among authors: kuo cc. Ann Neurol. 2021 Jun;89(6):1099-1113. doi: 10.1002/ana.26068. Epub 2021 Apr 9. Ann Neurol. 2021. PMID: 33745195

2

Characterization of lamotrigine inhibition of Na+ channels in rat hippocampal neurones.

Kuo CC, Lu L. Kuo CC, et al. Br J Pharmacol. 1997 Jul;121(6):1231-8. doi: 10.1038/sj.bjp.0701221. Br J Pharmacol. 1997. PMID: 9249262 Free PMC article.

3

Inhibition of Na(+) current by imipramine and related compounds: different binding kinetics as an inactivation stabilizer and as an open channel blocker.

Yang YC, Kuo CC. Yang YC, et al. Among authors: kuo cc. Mol Pharmacol. 2002 Nov;62(5):1228-37. doi: 10.1124/mol.62.5.1228. Mol Pharmacol. 2002. PMID: 12391287

4

The position of the fourth segment of domain 4 determines status of the inactivation gate in Na+ channels.

Yang YC, Kuo CC. Yang YC, et al. Among authors: kuo cc. J Neurosci. 2003 Jun 15;23(12):4922-30. doi: 10.1523/JNEUROSCI.23-12-04922.2003. J Neurosci. 2003. PMID: 12832514 Free PMC article.

5

Block of tetrodotoxin-resistant Na+ channel pore by multivalent cations: gating modification and Na+ flow dependence.

Kuo CC, Chen WY, Yang YC. Kuo CC, et al. J Gen Physiol. 2004 Jul;124(1):27-42. doi: 10.1085/jgp.200409054. J Gen Physiol. 2004. PMID: 15226363 Free PMC article.

6

An inactivation stabilizer of the Na+ channel acts as an opportunistic pore blocker modulated by external Na+.

Yang YC, Kuo CC. Yang YC, et al. Among authors: kuo cc. J Gen Physiol. 2005 May;125(5):465-81. doi: 10.1085/jgp.200409156. Epub 2005 Apr 11. J Gen Physiol. 2005. PMID: 15824190 Free PMC article.

7

A hydrophobic element secures S4 voltage sensor in position in resting Shaker K+ channels.

Yang YC, Own CJ, Kuo CC. Yang YC, et al. Among authors: kuo cc. J Physiol. 2007 Aug 1;582(Pt 3):1059-72. doi: 10.1113/jphysiol.2007.131490. Epub 2007 Apr 5. J Physiol. 2007. PMID: 17412765 Free PMC article.

8

The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channel.

Yang YC, Hsieh JY, Kuo CC. Yang YC, et al. Among authors: kuo cc. J Gen Physiol. 2009 Aug;134(2):95-113. doi: 10.1085/jgp.200810158. J Gen Physiol. 2009. PMID: 19635852 Free PMC article.

9

Ionic flow enhances low-affinity binding: a revised mechanistic view into Mg2+ block of NMDA receptors.

Yang YC, Lee CH, Kuo CC. Yang YC, et al. Among authors: kuo cc. J Physiol. 2010 Feb 15;588(Pt 4):633-50. doi: 10.1113/jphysiol.2009.178913. Epub 2009 Dec 21. J Physiol. 2010. PMID: 20026615 Free PMC article.

10

Lidocaine, carbamazepine, and imipramine have partially overlapping binding sites and additive inhibitory effect on neuronal Na+ channels.

Yang YC, Huang CS, Kuo CC. Yang YC, et al. Among authors: kuo cc. Anesthesiology. 2010 Jul;113(1):160-74. doi: 10.1097/ALN.0b013e3181dc1dd6. Anesthesiology. 2010. PMID: 20526191

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