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Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th17 lineage.
Zhu Y, Gumlaw N, Karman J, Zhao H, Zhang J, Jiang JL, Maniatis P, Edling A, Chuang WL, Siegel C, Shayman JA, Kaplan J, Jiang C, Cheng SH. Zhu Y, et al. Among authors: karman j. J Biol Chem. 2011 Apr 29;286(17):14787-94. doi: 10.1074/jbc.M111.218610. Epub 2011 Mar 14. J Biol Chem. 2011. PMID: 21402703 Free PMC article.
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